| abstract |
An anti-beta-A4 peptide antibody molecule comprising: (a) a VL variable region comprising complementarity determining regions, L-CDR1, L-CDR2 and LCDR3, wherein: (1) L-CDR1 comprises SEQ ID NO : 143: Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala; (2) L-CDR2 comprises SEQ ID NO: 144: Gly Ala Ser Ser Arg Ala Thr; and (3) L-CDR3 comprises SEQ ID NO: 95: Leu Gln Ile Tyr Asn Met Pro Ile; and (b) a variable VH region comprising complementarity determining regions, H-CDR1, H-CDR2 and CDR3, wherein: (1) H-CDR1 comprises SEQ ID NO: 146: Gly Phe Thr Phe Ser Ser Tyr Ala Met To be; (2) H-CDR2 comprises SEQ ID NO: 192: Ala Ile Asn Ala Ser Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly; and (3) H-CDR3 comprises SEQ ID NO: 93: Gly Lys Gly Asn Thr His Lys Pro Tyr Gly Tyr Val Arg Tyr Phe Asp Val. |