| abstract |
A polypeptide that binds to the human B-lymphocyte receptor (BCR) complex, wherein said polypeptide comprises: (I) the amino acid sequence of a variable region of the immunoglobulin light chain (VL) that is a humanized variant of the region variable of the light chain of an antibody to the natural BCR complex (VL DE BCC), wherein said amino acid sequence of said variable region of the immunoglobulin light chain (VL) is selected from the group consisting of SEQ ID NO: 12 , SEQ ID NO: 14, SEQ ID NO: 16, SEQ ID NO: 18 and SEQ ID NO: 20; and (II) the amino acid sequence of a variable region of the immunoglobulin heavy chain (VH) that is a humanized variant of the variable region of the heavy chain of an antibody to the natural BCR complex (VH DE BCC), in which said amino acid sequence of said variable region of the immunoglobulin heavy chain (VH) is selected from the group consisting of SEQ ID NO: 26, SEQ ID NO: 28, SEQ ID NO: 30 and SEQ ID NO: 36. |