| abstract |
A compound of Formula (I) ** Formula ** where R1 denotes absence or denotes A or Q-Het, Z denotes a group: where X denotes O, S or N, Y denotes C or N, T denotes C or N, or Z denotes a pyridine or a pyridazine group, Ra is absent or denotes OR3, CF3, Hal, NO2, Rb is absent or denotes one of the selected groups of A and COHet, R2 denotes H, Het, Q-Het, Cyc, A or OA, Het denotes a 4-9 membered monocyclic ring or a fused, spiro or bridged bicyclic ring, which is saturated, unsaturated or aromatic, containing 1 to 3 heteroatoms independently selected from N, O, S and a group CO, SO or SO2, and where 1 or H atoms can be replaced by A, OA, COA, CN, Hal, NO2, OR3, SOA and / or SO2A, Cyc denotes a saturated carbocyclic ring of 4-8 which optionally contains SO, SO2, CO, and optionally substituted once or twice by a group selected from CO (NR3) 2, and COHet, OR3, Het1, A, CH2Het1, NH2, NHCOA, OCH2Cyc1, SO2A and / or -SA (> = NH) (> = O), Q denotes an alkylene li neal or branched, which has 1 to 6 carbon atoms where 1 to 5 H atoms can be replaced by a group independently selected from OR3, Hal, N (R3) 2, and where 1 or 2 CH2 groups can be replaced by a group independently selected from CO, SO, SO2 and NR3, or Q denotes a 4-8 membered bivalent heterocyclic ring, which is saturated, unsaturated or aromatic and containing 1 to 3 heteroatoms independently selected from N, O and S, A denotes a linear or branched alkyl having 1 to 10 carbon atoms in which 1 to 7 H atoms can be replaced by a group independently selected from -OR3, Hal, NHSO2A, SO2A, SOA, N (R3) 2, and wherein 1, 2 or 3 non-adjacent groups -CH2- can be replaced by a group independently selected from -CO-, NR3 and / or -O-, Hal denotes F, Cl, Br or I, R3 denotes H or C1 -C6-alkyl wherein 1 H atom can be replaced by a group selected from OH, OC1-C6-alkyl, and Hal, Het1 denotes u n five or six-membered saturated monocyclic heterocycle containing 1-3 N and / or O atoms, which is optionally monosubstituted by A, Cyc1 denotes 3-7 atoms cycloalkyl, and pharmaceutically acceptable solvates, tautomers, salts, hydrates and stereoisomers thereof, including mixtures thereof in all proportions. |