http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2587939-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 |
| filingDate | 2013-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eac882e27f0f0e850ad2d25aecd8421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e9078a30d1e5c0ccf05ea611776a71 |
| publicationDate | 2016-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2587939-T3 |
| titleOfInvention | Pyrrolotriazinone derivatives |
| abstract | Compounds of formula I ** Formula ** where X denotes N or CR1, R1 denotes H, F, Cl, CH3, CH2OH, CH2CI, CH2Br, CF3, CHF2 or CH2F, R2 denotes H or A, Y denotes Ar1, Het1 or Cyc, Ar1 denotes phenyl or naphthyl, which is unsubstituted or mono, di, or trisubstituted by Hal, A, [C (R2) 2] pOR2, [C (R2) 2] pN (R2) 2, [C ( R2) 2] pHet2, NO2, CN, [C (R2) 2] pCOOR2, [C (R2) 2] pCON (R2) 2, NR2COA, NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, COHet3, O [C (R2) 2] mN (R2) 2, O [C (R2) 2] pAr2, O [C (R2) 2] pHet2, NHCOOA, NHCON (R2) 2, CHO and / or COA, Ar2 denotes phenyl, which is unsubstituted or mono or disubstituted by Hal, A, [C (R2) 2] pOR2, [C (R2) 2] pN (R2) 2, [C (R2 ) 2] pHet3, NO2, CN, [C (R2) 2] pCOOR, [C (R2) 2N (R2) 2, N (R2) 2COA, NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, COHet3, O [C (R2) 2] mN (R2) 2, O [C (R2) 2] pHet3, NHCOOA, NHCON (R2) 2, CHO and / or COA, Het1 denotes pyrrolidinyl, azetidinyl, tetrahydroimidazolyl, tetrahydrofuranyl, tetrahydropyrazolyl, tetrahydropyranyl, piperidinyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3ldioxolanil , piperazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl, quinolyl, 1,3-benzyloxy, 1,3-benzyl, ylolyl, 1,3-benzyl, ylolyl, 1,3-benzyl, ylolyl, 1,3-benzyl, ylolyl, 1,3-benzyl-yloxyloyl , imidazopyridyl or furo [3,2-b] pyridyl, each of which is unsubstituted or mono or disubstituted by Hal, A, [C (R2) 2] pOR2, [C (R2) 2] pN (R2) 2, [C (R2) 2] pHet2, [C (R2) 2] pAr2, NO2, CN, [C (R2) 2] pCOOR2, [C (R2) 2] pCON (R2) 2, NR2COA, NR2SO2A, [C (R2) 2] pSO2N (R2) 2, S (O) nA, C0Het3, O [C (R2) 2] mN (R2) 2, O [C (R2) 2] pAr2, O [C (R2 ) 2] pHet2, NHCOOA, NHCON (R2) 2, CHO, COA,> = S,> = NR and / or> = O, Cyc denotes cyclic alkyl with 3, 4, 5, 6 or 7 C atoms, which may be unsubstituted or monosubstituted by A, Hal, CN, or Ar2 or Het2, Het2 denotes pyrrolidinyl, azetidinyl, tetrahydroimidazolyl, tetrahydrofuranyl, tetrahydropyrazolyl, tetrahydropyranyl, piperidinyl, morpholinyl, hexahydropyridazinyl, hexahydropyridyl [ 1,3] dioxolanyl, piperazinyl, furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidyl, pyridazinyl, indolyl, isoindolyl, benzimidazolyl, indazolyl, benzodioxolyl, benzothiophenyl, benzofuranyl, imidazopyridyl or furo [3,2-b] pyridyl, each of which is unsubstituted or mono or disubstituted by Hal, A, [C (R2) 2] pOR2, [C (R2) 2 ] pN (R2) 2, [C (R2) 2] pHet3, [C (R2) 2] p, OHet3, [C (R2) 2] pAr2 NO2, CN, [C (R2) 2] pCOOR2, [C (R2) 2] pCON (R2) 2, NR2COA, NR2S02A, [C (R2) 2] pS02N (R2) 2, S (O) nA, COHet3 O [C (R2) z] mN (R2) 2, O [C (R2) 2] pAr2, O [C (R2) 2] pHet3, NHCOOA, NHCON (R2) 2, CHO, COA,> = S,> = NR and / or> = O, Het3 denotes dihydropyrrolyl, pyrrolidinyl , azetidinyl, oxethanil, tetrahydroimidazolyl, dihydropyrazolyl, tetrahydropyrazolyl, tetrahydrofuranyl, dihydropyridyl, tetrahydropyridyl, piperidinyl, morpholinyl, hexahydropyridazinyl, hexahydropyrimidinyl, [1,3] dioxolanyl, tetrahydropynyl razinyl, each of which is unsubstituted or mono or disubstituted by Hal, CN, OR2, COOR2, CON (R2) 2, S (O) nA, S (O) nAr, COA, A and / or> = O , A denotes unbranched or branched alkyl with 1-10 C atoms, where one or two non-adjacent CH and / or CH2 groups may be replaced by N, O and / or S atoms and where 1-7 atoms H can be replaced by F or Cl, Hal denotes F, CI, Br or I, m denotes 1, 2 or 3, p denotes 0, 1, 2, 3 or 4, with the proviso that, if R1 is absent, then Y is not 4-fluorophenyl, 3-bromophenyl, or 5-chloro-2-fluorophenyl, and excluding 2- (4-oxo-3H-pyrrolo [2,1-f] [1,2,4] triazin-2- yl) benzyl tert-butyl pyrrolidin-1-carboxylate and benzyl 2- (4-oxo-3H-pyrrolo [2,1- f] [1,2,4] triazin-2-yl) pyrrolidin-1-carboxylate, and its pharmaceutically acceptable solvates, salts, tautomers, and stereoisomers, including mixtures in all proportions. n denotes 0, 1 or 2, |
| priorityDate | 2012-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 355.