http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2587013-T3
Outgoing Links
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2003-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdbaa006d7e3002572840fc6c8e62dc8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73b0230e50293412c40cbac9185cf9f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_966e1a97b7e23213202343d0fd3ece3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_366058dd00664097b4bf8b4dae2f88e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9044e11a935385dd75d774f3b877ff45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f8d8fc80b02d4b8fef8c2f0c9bc4c38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_004f57a89e68ff76d2ffd11c6c673adb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46369ca70c75f7008d7b97e60dbbe4d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8199a4c9db49e18b2b8d2fbbe62b8b08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e85b59f67c88ebb61f855717b6dd6d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc1340ad203eb642495af71135b3a1af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42de8b136b2392690f83cca6e3f145bb |
| publicationDate | 2016-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2587013-T3 |
| titleOfInvention | Spirocyclic cyclohexane derivatives |
| abstract | Spirocyclic cyclohexane derivatives of general formula I, ** Formula ** where R1 and R2 represent, independently of each other, H, CHO, branched or unbranched, saturated or unsaturated (C1-5) alkyl, unsubstituted; or the groups R1 and R2 together represent CH2CH2OCH2CH2, CH2CH2NR11CH2CH2 or (CH2) 3-6; R11 being equal to H; or (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; R3 represents (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl, in each case substituted simply or multiplely or unsubstituted; or aryl or (hetero) C3-8 cycloalkyl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; W represents NR4, O or S; R4 being equal to H, saturated or unsaturated (C1-5) alkyl, branched or unbranched, substituted simply or multiple or unsubstituted; or substituted or unsubstituted aryl; R12 being equal to H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl, in each case substituted simply or multiplely or unsubstituted; or aryl, (hetero) C3-8 cycloalkyl or heteroaryl, in each case substituted in a simple or multiple or unsubstituted form, linked through a (C1-3) alkyl, in each case saturated or unsaturated, linear or branched ; OR13; or NR14R15; R5 represents (hetero) C3-8 cycloalkyl saturated or unsaturated, substituted simply or multiple or unsubstituted; aryl or heteroaryl substituted single or multiple or unsubstituted; or (hetero) C3-8 cycloalkyl or heteroaryl linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; R6 represents H; F, Cl, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, CN, COOR13, NR14R15; (C1-5) alkyl saturated or unsaturated, branched or unbranched, substituted simply or multiple or unsubstituted; aryl substituted single or multiple or unsubstituted; or single or multiple or unsubstituted substituted aryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; R7, R8, R9 and R10 represent, independently of each other, H, F, Cl, Br, I, NO2, CF3, OR13, SR13, SO2R13, SO2OR13, SO2NH2, CN, COOR13, NR14R15; (C1-5) alkyl, (hetero) C3-8 cycloalkyl, substituted in single or multiple or unsubstituted; aryl or heteroaryl substituted single or multiple or unsubstituted; or aryl, (hetero) C3-8 cycloalkyl or substituted or single or unsubstituted heteroaryl, linked through a (C1-3) alkyl, in each case saturated or unsaturated, branched or unbranched; R13 being equal to H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; or (hetero) C3-8 cycloalkyl, in each case saturated or unsaturated, unsubstituted; R14 and R15 mean, independently of each other, H, (C1-5) alkyl, in each case saturated or unsaturated, branched or unbranched, unsubstituted; or R14 and R15 together form CH2CH2OCH2CH2, CH2CH2NR16CH2CH2 or (CH2) 3-6, R16 being equal to H or (C1-5) alkyl saturated or unsaturated, branched or unbranched, unsubstituted; X represents NR17; where R17 represents H, saturated or unsaturated (C1-5) alkyl, branched or unbranched; COR12 or SO2R12; where the term "substituted" in relation to "alkyl" means the substitution of one or more hydrogen groups by F, Cl, Br, I, -CN, NH2, NH-alkyl, NH- (hetero) cycloalkyl, NH- alkyl-OH, N (alkyl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, S-alkyl, S- (hetero) cycloalkyl, S-alkyl-OH; Salkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, O-alkyl-OH, CHO, C (> = O) (C1-6) alkyl, C (> = S) (C1-6) alkyl , C (> = O) - (hetero) cycloalkyl, C (> = S) - (hetero) cycloalkyl, CO2H, CO2-alkyl, C (> = O) NH2, C (> = O) NH-alkyl, C (> = O) NH- (hetero) cycloalkyl, C (> = O) N (alkyl) 2, C (> = O) N ((hetero) -cycloalkyl) 2, SO-alkyl, SO2-alkyl, SO2NH2, SO3H or (hetero) cycloalkyl, aryl or heteroaryl; and by the concept "substituted simply or multiplely" in relation to "aryl" and "(hetero) cycloalkyl" is meant single or multiple substitution, for example double, triple, quadruple or quintuple, of one or more hydrogen atoms of the ring system by F, Cl, Br, I, CN, NH2, NH-alkyl, NH- (hetero) cycloalkyl, NH-alkyl-OH, N (alkyl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, Salkyl, S- (hetero) cycloalkyl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, Oalkyl-OH, CHO , C (> = O) (C1-6) alkyl, C (> = S) (C1-6) alkyl, C (> = O) - (hetero) cycloalkyl, C (> = S) - (hetero) cycloalkyl , CO2H, CO2-alkyl, C (> = O) NH2, C (> = O) NH-alkyl, C (> = O) NH- (hetero) cycloalkyl, C (> = O) N (alkyl) 2, C (> = O) N ((hetero) -cycloalkyl) 2, S (O) -alkyl, SO2-alkyl, SO2NH2, SO3H, CF3,> = O,> = S; alkyl, (hetero) cycloalkyl or heteroaryl; by the term "single or multiple substituted" in relation to "heteroaryl" is meant the simple or multiple substitution, for example double, triple, quadruple or quintuple, of one or more hydrogen atoms of the ring system by F, Cl , Br, I, CN, NH2, NH-alkyl, NH-aryl, NH-heteroaryl, NH-alkylaryl, NH-alkylheteroaryl, NH- (hetero) cycloalkyl, NH-alkyl-OH, N (alkyl) 2, N ( alkylaryl) 2, N (alkylheteroaryl) 2, N ((hetero) cycloalkyl) 2, N (alkyl-OH) 2, NO2, SH, S-alkyl, S- (hetero) cycloalkyl, S-aryl, S-heteroaryl, S-alkylaryl, S-alkylheteroaryl, S-alkyl-OH, S-alkyl-SH, OH, O-alkyl, O- (hetero) cycloalkyl, O-aryl, O-heteroaryl, O-alkylaryl, O-alkylheteroaryl, O25 alkyl-OH, CHO, C (> = O) (C1-6) alkyl, C (> = S) (C1-6) alkyl, C (> = O) - (hetero) cycloalkyl, C (> = S) - (hetero) cycloalkyl, CO2H, CO2-alkyl, C (> = O) NH2, C (> = O) NH-alkyl, C (> = O) NH- (hetero) cycloalkyl, C (> = O) N (alkyl) 2, C (> = O) N ((hetero) cycloalkyl) 2, S (O) -alkyl, SO2-alkyl, SO2NH2, SO 3H, CF3,> = O,> = S; alkyl, (hetero) cycloalkyl, aryl and / or heteroaryl; the term "aryl" means a carbocyclic ring system with at least one aromatic ring but without heteroatoms in any of the rings, the aryl groups being able to be condensed with other saturated, (partially) unsaturated or aromatic ring systems; the term "heteroaryl" represents a cyclic aromatic group of 5, 6 or 7 members that contains at least 1 and if necessary also 2, 3, 4 or 5 heteroatoms, the heteroatoms being the same or different, nitrogen, oxygen or sulfur and the heterocycle may also be part of a bicyclic or polycyclic system; the expression "(hetero) cycloalkyl" represents a cyclic hydrocarbon of 3, 4, 5, 6, 7 or 8 carbon atoms, the hydrocarbons may be saturated or unsaturated, but not aromatic, and one or two carbon atoms may be substituted if necessary by a heteroatom S, N or O; in the form of racemate, enantiomers, diastereoisomers, mixture of enantiomers or diastereoisomers or of an individual enantiomer or diastereoisomer; in the form of bases and / or salts of physiologically compatible acids or cations. |
| priorityDate | 2002-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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