| abstract |
A zinc finger protein comprising a non-canonical (non-C2H2) zinc finger, wherein the non-canonical zinc finger has a helical part involved in DNA binding and where at least one zinc finger comprises the sequence Cys- (XA) 2-4-Cys- (XB) 12-His- (XC) 3-5-Cys- (XD) 1-10 (SEQ ID NO: 3), where XA, XB, XC and XD can being any amino acid and His- (XC) 3-5-Cys (XD) 1-10 comprises one of the sequences as shown in any of SEQ ID NO: 14-80, 83-87 and 89-92 and additionally in where zinc finger protein is genetically modified to bind to a target sequence. |