| abstract |
An antibody fragment or purified antibody derivative, wherein said antibody fragment or antibody derivative - recognizes and binds to the CDR3 loop of the α chain of an invariant T cell antigen receptor (TCR) in an invariant NK T cell , - (i) binds (ii) inhibits the expansion or activation of at least one sub-population of T cells selected from the group of: NK T cells, CD1d-reactive T cells and JαQ + T cells, and - does not recognize or recognize substantially binds to other molecules, wherein said antibody fragment is a monovalent antibody or a Fab molecule, and wherein said antibody derivative is an antibody conjugated to a toxin or radiolabel. |