abstract |
A compound of formula (D): ** Formula ** in which: La is CH2, O, NH or S; Ar is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; Y is an optionally substituted group selected from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl; Z is C (> = O), OC (> = O), NHC (> = O), C (> = S), S (> = O) x, OS (> = O) x, NHS (> = O) x, where x is 1 or 2; R7 and R8 are independently selected from H, unsubstituted C1-C4 alkyl, substituted C1-C4 alkyl, unsubstituted C1-C4 heteroalkyl, substituted C1-C4 heteroalkyl, unsubstituted C3-C6 cycloalkyl, substituted C3-C6 cycloalkyl, C2 heterocycloalkyl -C6 unsubstituted and substituted C2-C6 heterocycloalkyl; or R7 and R8 together form a bond; R6 is H, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 heteroalkyl, C1-C6 alkoxyalkyl, C1-C8 alkylaminoalkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted aryl, C2- heterocycloalkyl C8 substituted or unsubstituted, substituted or unsubstituted heteroaryl, (C1-C4) alkyl aryl, (C1-C4) alkyl heteroaryl, (C1-C4) alkyl cycloalkyl (C3-C8) or (C1-C4) alkyl heterocycloalkyl (C2 -C8) or a pharmaceutically acceptable salt thereof. |