| abstract |
An isolated monoclonal antibody or antigen-binding antibody fragment that binds lysophosphatidic acid (LPA) under physiological conditions and that comprises at least one immunoglobulin heavy chain variable domain that comprises three chain complementary determining regions (CDRs) heavy having the amino acid sequences of SEQ ID NOs: 56, 57, and 58 and a light chain variable domain comprising three light chain CDRs having the amino acid sequences of SEQ ID NOs: 59, 60, and 61, wherein said monoclonal antibody or antigen-binding antibody fragment optionally: a. is selected from the group consisting of a chimeric antibody, a humanized antibody, a full-length antibody, an affinity matured antibody, or an antigen binding fragment of any such antibody; and / or b. it is conjugated to a residue selected from the group consisting of a polymer, a radionuclide, a chemotherapeutic agent and a detection agent. |