| abstract |
A compound of the general formula: ** Formula ** where: X and Y are each a monosaccharide unit where each hydroxyl group not included in a glycosidic bond is independently substituted by a SO3M or H group, where M is any pharmaceutically acceptable cation ; X and Y are either D- or L-hexose or pentose; And it is an open ring or cyclic form; Z is O, S, an oxidation state greater than S, or a bond, and is bound to the anomeric carbon when Y is a reducing monosaccharide; R1 is a connector selected from the group that includes alkylene, alkenylene, alkynylene, arylene, heteroalkylene, heteroarylene, acylene, aroylene, alkyleneamide, alkylenethioamido, triazolylene, an oxymethyl [1,2,3] -triazol-1-yl linker or is a link; R2 is a lipophilic moiety selected from the group that includes, cholestanyl, cholate, deoxycholate, propyl stearamide; n is an integer from 0 to 6; The sulfation level of each compound is between 70 and 100% of the total hydroxyl groups, where when X and Y are ribose, and R1 is a bond, then R2 is not a C18 group. |