| abstract |
A compound of Formula II: ** Formula ** in which: m is 0, 1 or 2; n is 0, 1, 2 or 3; R2 is C1-6-R5 alkylene, C1-6-L-R5 alkylene or C1-6-L-alkylene C1-6-R5 alkylene; L is -O-, -C (O) -, -NHS (O) 2-, -S (O) 2NH-, -C (O) NH- or -NHC (O) -; each R3 is independently hydrogen, deuterium or C1-6 alkyl; each R4 is independently hydrogen, deuterium or C1-6 alkyl; R5 is cycloalkyl, aryl, heteroaryl or heterocyclyl; wherein said cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of C1-6 alkyl, halo, cycloalkyl, heterocyclyl, heteroaryl, -N (R20) (R22), -C (O) -OR20, -CN and -O-R20; wherein said C1-6 alkyl or heteroaryl are optionally further substituted with one, two or three substituents independently selected from the group consisting of halo, C1-6 alkyl and aryl; and wherein said C1-6 alkyl is optionally further substituted with one, two or three halo; each R10 is independently selected from the group consisting of halo, -NO) 2, -CN, -SF5, -Si (CH3) 3, -OR20, -S-R20, -C (O) -R20, -C ( O) -OR20, -N (R20) (R22), -C (O) -N (R20) (R22), -N (R20) -C (O) -R22, -N (R20) -C (O ) -OR22, - N (R20) -S (O) 2-R26, -S (O) 2-R20, -OS (O) 2-R20, -S (O) 2-N (R20) (R22) , C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl and heterocyclyl; wherein said C1-6 alkyl, C2-4 alkenyl, C2-4 alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halo, -NO2, aryl, heterocyclyl, heteroaryl, C1-6 alkyl, C1-3 haloalkyl, cycloalkyl, -N (R20) (R22), -C (O) -R20, -C (O) -OR20, -C (O) -N (R20 ) (R22), -CN and -O-R20; R17 is halo, or C1-6 alkyl; R20 and R22 are each independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl; wherein C1-6 alkyl, C2-6 alkenyl, C1-6 alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, C1- alkyl 4, acylamino, oxo, -NO2, -S (O) 2R26, -CN, C1-3 alkoxy, -CF3, -OCF3, - OCH2CF3, -C (O) -NH2, aryl, cycloalkyl and heteroaryl; and wherein said heteroaryl is optionally further substituted with C1-4 alkyl or cycloalkyl; or when R20 and R22 are attached to a common nitrogen atom, R20 and R22 can be joined to form a heterocyclic or heteroaryl ring which is then optionally substituted with one, two or three substituents independently selected from the group consisting of hydroxyl, halo, C1-4 alkyl, aralkyl, aryloxy, aralkyloxy, acylamino, -NO2, -S (O) 2R26, -CN, C1-3 alkoxy, -CF3, -OCF3, aryl, heteroaryl and cycloalkyl; and each R26 is independently selected from the group consisting of hydrogen, C1-4 alkyl, aryl and cycloalkyl; wherein C1-4 alkyl, aryl and cycloalkyl may be further substituted with 1 to 3 substituents independently selected from the group consisting of hydroxyl, halo, C1-4 alkoxy, -CF3 and -OCF3; where in each case independently a cycloalkyl group is from 3 to 20 carbon atoms; an aryl group is 6 to 20 carbon atoms; a heteroaryl group comprises single or multiple rings comprising 1 to 15 carbon atoms and 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur in at least one ring; and a heterocyclyl group is a saturated monorax group having a single ring or multiple condensed rings, having 1 to 40 carbon atoms and 1 to 4 heteroatoms, selected from nitrogen, sulfur, phosphorus and / or oxygen in the ring; or a salt, an ester, a stereoisomer, a mixture of stereoisomers or a pharmaceutically acceptable tautomer thereof. |