http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2583006-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3219dba701f53c6a9c2edae5191e25b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 |
| filingDate | 2010-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b28ae29ae64e1f80efbb8cf02157f31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_722d0545b1c9bdb6f9b2747a910a0328 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49c3073132d9743f121eb5e00f6f7662 |
| publicationDate | 2016-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2583006-T3 |
| titleOfInvention | Compounds of 3-substituted-8-substituted-3H-imidazo [5,1-d] [1,2,3,5-tetrazin-4-one and their use |
| abstract | A compound selected from compounds of the following formula and salts, hydrates and solvates thereof: ** Formula ** in which: -A is independently -A1, -A3 or -A6; and -B is independently -B1, -B2, -B3, -B4, -B5, -B6, -B7, - B8, -B9, -B10, -B11, -B12, -B13 or -B14; or in which: -A is independently -A4; and -B is independently -B1, -B2, -B3, -B4, -B5, -B6, -B7, -B8, -B10, - B11, -B12, -B13 or -B14; wherein: -A1 is independently C5-12 heteroaryl and is optionally substituted with one or more groups selected from: -F, -Cl, -Br, -I, -RZ1 -CF3, -OH, -ORZ1, -OCF3, -SRZ1, -NH2, -NHRZ1, -NRZ1 2, pyrrolidino, piperidino, morpholino, piperizino, (N-C1-4 alkyl) -piperizino, -C (> = O) OH, -C (> = O) ORZ1, -C (> = O) RZ1, -OC (> = O) RZ1, -C (> = O) NH2, -C (> = O) NHRZ1, -C (> = O) NRZ1 2, -C (> = O) -pyrrolidino, -C (> = O) -piperidino, -C (> = O) -morpholine, -C (> = O) -piperizino, -C (> = O) - (N-C1-alkyl 4) -piperizine, -NHC (> = O) RZ1 -NRZ1C (> = O) RZ1, -OC (> = O) NH2, -OC (> = O) NHRZ1, -OC (> = O) NRZ1 2, -OC (> = O) -pyrrolidino, -OC (> = O) -piperidino, -OC (> = O) -morpholino, -OC (> = O) -piperizino, (N-C1-4 alkyl) -piperizino , -NHC (> = O) OH, -NHC (> = O) ORZ1, -NRZ1C (> = O) ORZ1, -NHC (> = O) NH2, -NHC (> = O) NHRZ1, -NHC (> = O) NRZ1 2, -NHC (> = O) -pyrrolidino, -NHC (> = O) -piperidino, -NHC (> = O) -morpholino, -NHC (> = O) -piperizino, -NHC (> = O) - (N-C 1-4 alkyl) -piperizino, -NO2 and -CN; n where each -RZ1 is independently saturated aliphatic C1-4 alkyl, aliphatic C3-6 alkynyl, saturated C3-6 cycloalkyl, C5-6 heteroaryl, -Ph or -CH2-Ph, wherein each of said C3-6 cycloalkyl, C5-6 heteroaryl and -Ph is optionally substituted with one or more substituents selected from -F, -Cl, -Br, -I, -RZ1A, -CF3, -OH, -ORZ1A and -OCF3, where each -RZ1A is independently saturated C1-4 aliphatic alkyl, and additionally wherein two adjacent substituents can together form -O-CH2-O- or -O-CH2CH2-O-; -A3 is independently -C (> = NH) NH2, -C (> = NH) NHRZ3 or -C (> = NH) NRZ3 2, -C (> = NH) -pyrrolidine, -C (> = NH) - piperidino, -C (> = NH) -morpholino, -C (> = NH) -piperizino or -C (> = NH) - (N-C1-4 alkyl) -piperizino, where: -RZ3 is independently C1 alkyl -4 saturated aliphatic, saturated C3-6 cycloalkyl, C5-6 heteroaryl, -CH2- C5-6 heteroaryl, -Ph or -CH2-Ph, wherein each of said C1-4 alkyl, C3-6 cycloalkyl, C5 heteroaryl -6 and -Ph is optionally substituted with one or more groups selected from: -F, -Cl, -Br, -I, -RZ3A, -CF3, -OH, -ORZ3A, -OCF3, -SRZ3A, -NH2, - NHRZ3A, -NRZ3A 2, pyrrolidino, piperidino, morpholino, piperizino, (N-C1-4 alkyl) -piperizino, -C (> = O) OH, -C (> = O) ORZ3A, -C (> = O) RZ3A, -OC (> = O) RZ3A, -C (> = O) NH2, -C (> = O) NHRZ3A, -C (> = O) NRZ3A 2, -C (> = O) -pyrrolidine, - C (> = O) -piperidino, -C (> = O) -morpholine, -C (> = O) -piperizino, -C (> = O) - (N-C1-4 alkyl) -piperizino, -NHC (> = O) RZ3A, -NRZ3AC (> = O) RZ3A, -OC (> = O) NH2, -OC (> = O) NHRZ3A, -OC (> = O) NRZ3A 2, -OC (> = O ) -pyrrolidine, -OC (> = O) -piperidino, -O C (> = O) -morpholino, -OC (> = O) -piperizino, (N-C1-4 alkyl) -piperizino, -NHC (> = O) OH, -NHC (> = O) ORZ3A, -NRZ3AC (> = O) ORZ3A, -NHC (> = O) NH2, -NHC (> = O) NHRZ3A, -NHC (> = O) NRZ3A 2, -NHC (> = O) -pyrrolidine, -NHC (> = O) -piperidino, -NHC (> = O) -morpholino, -NHC (> = O) -piperizino, -NHC (> = O) - (N-C1-4 alkyl) -piperizino, -NO2 and -CN, |
| priorityDate | 2009-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 429.