| abstract |
A chimeric protein for use in a method of treatment with a biologically active molecule and two immunoglobulin constant regions or parts thereof, wherein the chimeric protein comprises a first polypeptide chain and a second polypeptide chain, wherein the first chain Polypeptide comprises the biologically active molecule and a constant region of immunoglobulin or part thereof, which is a neonatal receptor binding component (FcRn), and wherein the biologically active molecule is a protein selected from the group consisting of a cytokine. , a hormone and a clotting factor; and wherein the second polypeptide chain consists of a constant region of immunoglobulin, or a part thereof, which is an FcRn binding component and optionally a molecule with a molecular weight not greater than 2 kD, |