http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2582471-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e0fe3e209af9379ae4a171398592613 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06191 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2012-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3131b091bf333d2981198a42646e832c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_166dd27e939a555a4be9ec3ee7414377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb93fd2639a5e99ac01ccdcdb2afd26a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e861af053bb3f3ac52c9a6fa817849d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29a8af3ece0e58a3b86df0ce11daeaf1 |
| publicationDate | 2016-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2582471-T3 |
| titleOfInvention | Polybasic inhibitors of the bacterial outflow pump containing boron and therapeutic uses thereof |
| abstract | Compound having the structure of formula I or pharmaceutically acceptable salt thereof: ** Formula ** in which: R1 is selected from the group consisting of C1-C6 alkyl, C3-C7 carbocyclyl, heterocyclyl, aryl and heteroaryl, each optionally substituted with one or more substituents selected independently from the group consisting of a halogen, C1-C7 alkyl optionally substituted with one or more halogens, C3-C7 carbocyclyl, -OR2, -SR2, -SO2R2, -SO2NHR2, -N (R2 ) 2, -CN and -CO2-C1-C4-alkyl; each R2 is independently selected from the group consisting of H and C1-C6 alkyl optionally substituted with one or more halogens; A is -C (O) - or CH2; Z is selected from the group consisting of -CH2-, -C (O) -, -S (O) 2-, -C (O) O-, -C (O) S -, - C (O) NH- and -S (O) 2NH-; Q is selected from the group consisting of -NR3R4, -CHR3R4, ** Formula ** and; R3 is selected from the group consisting of -CH2 [CH (R5)] pCH (R6) NH2, -CH (CHR6NH2) 2 and -CH2C (OH) (CH2NH2) 2; R4 is selected from the group consisting of H and -CH2 [CH (R5)] pCH (R6) NH2; each R5 is independently selected from the group consisting of H, -OH, halogen, and C1-C4 alkyl substituted with one or more -OH or halogen; each R6 is independently selected from the group consisting of H and C1-C4 alkyl substituted with one or more - OH or halogen; each R7 is independently selected from the group consisting of H and C1-C4 alkyl substituted with one or more - OH or NH2, or optionally, two R7s can be linked by - (CH2) m- to form a bicyclic ring, where m it is an integer from 1 to 3; each R8 is independently selected from the group consisting of H, -NH2, -CH2NH2, -OH and -CH2OH; Y is selected from the group consisting of CHR9, O, S, SO2 and NR2; W is CHR8; R9 is selected from the group consisting of H, -NH2, -OH and C1-C4 alkyl substituted with one or more -OH or NH2; T is selected from the group consisting of CH2, O, S, and NR2; R10 is selected from the group consisting of H and OH, with the limitation that when R10 is OH, T is CH2; |
| priorityDate | 2011-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.