abstract |
A composition comprising a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein, wherein the insulin-like protein is an insulin homologue that has at least 50% of the activity of insulin and has 90% or more sequence identity at amino acid level with sec. with no. Ident .: 1, where the polysaccharide is polysalic acid, comprising between 2 and 125 units of sialic acid, and where at least 85% of the protein derivatives are derivatized only at the N-terminal of the B chain of insulin protein or insulin-like. |