abstract |
An anti-sclerostin antibody or fragment thereof for use in a method to inhibit bone resorption in a human being, the method comprising administering said anti-sclerostin antibody or fragment thereof to a human in an amount of 1 mg / kg a 5 mg / kg, where the anti-sclerostin antibody or fragment thereof demonstrates a sclerostin binding affinity of SEQ ID NO: 1 of less than or equal to 1 x 107 M and cross-blocks the sclerostin binding of a antibody comprising the CDRs of SEQ ID NO: 245, 246, 247, 78, 79 and 80 or the CDRs of SEQ ID NO: 284, 285, 286, 296, 297 and 298 or cross-blocked by the binding to sclerostin by said antibody, where: - SEQ ID NO: 245> = Asp Tyr Asn Met His; - SEQ ID NO: 246> = Glu Ile Asn Pro Asn Ser Gly Gly Ala Gly Tyr Asn Gln Lys Phe Lys Gly; - SEQ ID NO: 247> = Leu Gly Tyr Asp Asp Ile Tyr Asp Asp Trp Tyr Phe Asp Val; - SEQ ID NO: 78> = Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn; - SEQ ID NO: 79> = Tyr Thr Ser Arg Leu Leu Ser; and - SEQ ID NO: 80> = Gln Gln Gly Asp Thr Leu Pro Tyr Thr; and - SEQ ID NO: 284> = Arg Ala Ser Ser Ser Val Thr Ser Ser Tyr Leu Asn; - SEQ ID NO: 285> = Ser Thr Ser Asn Leu Ala Ser; - SEQ ID NO: 286> = Gln Gln Tyr Asp Phe Phe Pro Ser Thr; - SEQ ID NO: 296> = Asp Tyr Tyr Met Asn; - SEQ ID NO: 297> = Asp Ile Asn Pro Tyr Asn Asp Asp Thr Thr Tyr Asn His Lys Phe Lys Gly; and - SEQ ID NO: 298> = Glu Thr Ala Val Ile Thr Thr Asn Ala Met Asp. |