| abstract |
Solid pharmaceutical composition comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of cardiovascular disorders, in which both amlodipine or a pharmaceutically acceptable salt thereof such as losartan or a pharmaceutically acceptable salt thereof is in the form of granules separated from each other, and the composition comprises losartan or a pharmaceutically acceptable salt thereof in an amount ranging from 3 to 25% by weight based on the total weight of the composition, in which the dissolution rate of amlodipine measured by the USP vane method, 50 rpm at 37 ° C, is 80% or more thereof, in 30 minutes and in a pH range of 1.0 to 2, 0. |