http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2579830-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01f7d3d9295f6bf513bd55ec626cf461 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 |
| filingDate | 2012-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e7c707210f20108c70ba987810ee1c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22bef7f4b876a2379551ae0d41a30fa1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51180c461c1872620e3e8d3c5e1ec78c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebc0a44a66f088a8c3e1a79cc8af96d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1217b043a7963420775ea39b356c64df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0505c0a016c54cd706f7bace649e690 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4e5e3277c23f7a23404e43d314e29f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_714322cd427423a87120b33f4ba5b602 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93fdcedaafd3b4e30525739e21137f97 |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2579830-T3 |
| titleOfInvention | Diaminopyrimidine derivatives and procedures for their preparation |
| abstract | A use of a compound of Formula 1 or its pharmaceutically acceptable salt for the manufacture of a medicament for preventing or treating a dysfunction of gastrointestinal motility: ** Formula ** in which, R1 is a phenyl group substituted with one or more substituents selected from the group consisting of hydroxy, amino, halogen, cyano, nitro, hydroxycarbonyl, C1-5 alkyl (in which C1-5 alkyl is optionally substituted with halogen or amino), C2-6 alkenyl, C2-6 alkynyl , C1-5 alkoxy (wherein C1-5 alkoxy is optionally substituted with halogen), C1-5 alkylthio, mono- or di-C1-5-amino alkyl, C1-5 alkyl sulfonylamino, C1- alkyl 5-carbonylamino, C1-5 alkoxycarbonyl, aminosulfonyl, aminocarbonyl, C1-5 alkylcarbonyl and benzyloxycarbonylamino; or a heteroaryl group selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, furanyl, pyrrolyl, thiophenyl, naphthyl, indanyl, quinolinyl, quinolinonyl, chromenonyl, dihydroindolonyl, iso -indole-1,3-isoonononyl -dionyl, dihydrobenzimidazolonyl, benzoxazolonyl, benzofuranyl, benzothiophenyl, benzo [d] [1,3] dioxolyl, dihydrobenzo [1,4] dioxinyl, indolyl, indolinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl and which may be in the group heterodazoyl, indazolyl optionally substituted with one or more substituents selected from the group consisting of amino, di-C1-5-alkyl, cyano, nitro, halogen, C1-5 alkyl (wherein C1-5 alkyl is optionally substituted with halogen) , C1-5 alkoxy (wherein C1-5 alkoxy is optionally substituted with halogen), acetyl and C1-5 alkyl sulfonyl, R2 is a nitrogen containing cyclic group selected from the group consisting of the following Formulas A to D (in which * in Formulas A to D represents the position attached to the compound of Formula 1), ** Formula ** R3 is a C1-5 alkyl group optionally substituted with phenyl; or a C2-6 alkenyl group optionally substituted with phenyl or C3-6 cycloalkyl, R4 is hydrogen; a C1-5 alkyl group optionally substituted with a substituent selected from the group consisting of hydroxy, C1-5 alkoxy, benzylamino (in which the benzylamino is optionally substituted with halogen), phenylamino, C1-5-amino alkyl, C3 cycloalkylamino -6, pyrrolidinyl and hydroxy-C1-5-alkyl; a C1-5 alkoxycarbonyl group; a hydroxycarbonyl group; an aminocarbonyl group; a formyl group; or an oxo group (> = O), R5 is hydrogen; a hydroxyl group; a C1-5 alkoxy group; a phenoxy group; a benzyloxy group; a C1-5 alkyl group optionally substituted with a substituent selected from the group consisting of amino, C1-5 alkoxycarbonylamino and mono- or di-C1-5 alkyl; or a group selected from the group consisting of the following Formulas E to I (in which * in Formulas E to I represents the position attached to one of the compounds of Formulas A to D), ** Formula ** R6 is hydrogen; a hydroxyl group; or a C1-5 alkyl group optionally substituted with hydroxy, X is -CH (R7) -; -C (> = O) -; -N (R8) -; -OR-; or -S-, R7 is hydrogen; a hydroxyl group; an aminocarbonyl group; a phenyl group; or a C1-5 alkyl group optionally substituted with piperidinyl or hydroxy, R4 and R5, R5 and R6, R4 and R6 or R5 and R7 may be linked together to form a pentagonal or hexagonal ring, R8 is hydrogen; a C1-5 alkyl group; a C1-5 alkoxycarbonyl group; a phenyl group optionally substituted with C1-5 alkoxy or halogen, R9 is a C1-10 alkyl group optionally substituted with a substituent selected from the group consisting of hydroxy, halogen, C1-5 alkoxy, amino, C1-5 alkoxycarbonylamino, benzyloxycarbonylamino , mono- or dialkyl C1-5-amino, C1-5 alkoxy-C1-5 alkyloxy, phenoxy, benzyloxy, phenyl (wherein the phenyl is optionally substituted with one or more substituents selected from the group consisting of halogen, amino , C1-5 alkoxy and hydroxy), thiophenyl, pyridinyl, indolyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, furanyl, pyrrolyl, piperidinyl, piperazinyl (in which piperazinyl is optionally substituted with benzyl), C3-6, acetyl and benzoyl; a C3-6 cycloalkyl group; a piperidinyl group optionally substituted with C1-5 alkoxycarbonyl; a C1-10 alkenyl group optionally substituted with phenyl; a trifluoromethyl group; a trifluoroethyl group; or a phenyl group optionally substituted with halogen, R10 is hydrogen; or a C1-5 alkyl group, R11 and R12 are each independently hydrogen; a C1-10 alkyl group optionally substituted with a substituent selected from the group consisting of amino, C1-5 alkoxycarbonylamino, hydroxy, C1-5-thio alkyl, C3-10 cycloalkyl, phenyl (wherein the phenyl is optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-5 alkyl, mono- or di-C1-5 alkyl, trifluoromethyl, halogen, C1-5 alkoxy and C1-5 alkylcarbonyloxy), thiophenyl , pyrrolyl, furanyl (in which furanyl is optionally substituted with mono- or di-C1-5 alkyl), pyridinyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, thiazolyl and benzyloxy; a piperidinyl group optionally substituted with benzyl, benzoyl, C1-5 alkyl, or C1-5 alkylcarbonyl; an azetidinyl group optionally substituted with C1-5 alkoxycarbonyl; a C1-5 alkyl sulfonyl group; a phenylsulfonyl group (in which the phenyl moiety is optionally substituted with halogen); or a C3-10 cycloalkyl group. |
| priorityDate | 2011-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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