http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2578290-T3
Outgoing Links
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2011-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03985bb3752ab8847afc82eee6e42d82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74f881b2ccbce0cc9210480be4fe94c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92f4220e288848815de6729a97539cd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f3a2d2ffa6c6053e6af8ebda559969f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_638feeffb3ae00c500f13ffd97eb9227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab75fe885504110153fd36d13faaa1e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aebb16e2474bcf0e307e09973418bccb |
| publicationDate | 2016-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2578290-T3 |
| titleOfInvention | Oxazoline and isoxazoline derivatives as CRAC modulators |
| abstract | A compound of formula (Id): ** Formula ** in which the ring ** Formula ** is selected from formula (v) to (vii): ** Formula ** R is selected from alkyl, haloalkyl, cycloalkyl , cycloalkenyl, aryl, heteroaryl, heterocyclyl, -C (O) NR6R7, - C (O) OR6 and -C (O) R6; ring W is selected from aryl, heteroaryl, cycloalkyl, and heterocyclyl; R1, which may be the same or different at each occurrence, is independently selected from halo, cyano, nitro, hydroxyl, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, aryl, heteroaryl, heterocyclyl, -S (O) nR6, -NR6S ( O) 2R7, - NR6 (CR8R9) nC (O) OR6, -NR6 (CR8R9) nC (O) R6, -NR6 (CR8R9) nC (O) NR6R7, -C (O) NR6R7, -C (O) ( O) R6, -C (O) R6, - OC (O) R6 and -OC (O) NR6R7; R2 is selected from hydrogen, halo, hydroxyl, cyano, nitro, alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkoxy, -C (O) OR6, -NR6R7, -C (O) R6 , -NHS (O) 2R7 and -NHC (O) R6; R3, which may be the same or different at each occurrence, is independently selected from hydrogen, halo, hydroxyl, alkyl, alkoxy, haloalkyl, haloalkoxy, -NR6R7, -NR6S (O) 2R7, -C (O) NR6R7, and -C ( O) OR6; R4 and R5, which may be the same or different at each occurrence, are independently selected from hydrogen, halo, -OR10, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, - (CR8R9) nC (O) NR6R7, - C (O) R6 and - (CR8R9) nC (O) OR6; provided that when either R4 or R5 in Y is -OR10, then R10 is not hydrogen; or R4 and R5, taken together with the carbon atom to which they are attached, can form a substituted or unsubstituted 3- to 7-membered carbocyclic or heterocyclic ring; or any one of R4 and R5 at X and any one of R4 and R5 at Y combined together, when attached to carbon atoms, can form a 4- to 7-membered substituted or unsubstituted heterocyclic ring to give a heterocyclic ring bicyclic; ring D is selected from ** Formula ** where both A1 and A2 are C or N; G is selected from NR12 and O; R12 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl; R10 is selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl; R6 and R7, which may be the same or different at each occurrence, are independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl; or R6 and R7, taken together with the nitrogen atom to which they are attached, can form a substituted or unsubstituted 3- to 14-membered heterocyclic ring; R8 and R9, which may be the same or different at each occurrence, are independently selected from hydrogen, halo, alkyl, and alkoxy; or R8 and R9, taken together with the carbon atom to which they are attached, can form a 3- to 6-membered cyclic ring, in which the cyclic ring can be carbocyclic or heterocyclic; n is an integer ranging from 0 to 2, inclusive; p is an integer ranging from 0 to 5, inclusive; q is an integer ranging from 1 to 4, inclusive; wherein alkyl, haloalkyl, hydroxyalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkoxy, aryl, heteroaryl, heterocyclyl, wherever they occur, may optionally be substituted with one or more substituents independently selected from hydroxy, halo , cyano, nitro, oxo (> = O), thio (> = S), alkyl, haloalkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, heteroaryl, heterocyclic ring, heterocyclylalkyl, heteroarylalkyl, -C (O ) ORx, -C (O) Rx, -C (S) RX, -C (O) NRxRy, -NRxC (O) NyRz, - N (Rx) S (O) Ry, -N (Rx) S (O ) 2Ry, -NRxRy, -NRxC (O) Ry, -NRxC (S) Ry, -NRxC (S) NRyRz, -S (O) 2NRxRy, -ORx, -OC (O) Rx, - OC (O) NRxRy , -RxC (O) ORy, -RxC (O) NRyRz, -RxC (O) Ry, -SRx and -S (O) 2Rx; wherein each occurrence of Rx, Ry and Rz are independently selected from hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclylalkyl ring, and heteroarylalkyl; where alkyl refers to an alkane derived hydrocarbon radical that includes only carbon and hydrogen atoms in the main chain, has no unsaturation, has from one to six carbon atoms, and is attached to the rest of the molecule via a bond simple; wherein alkenyl refers to a hydrocarbon radical containing from 2 to 10 carbon atoms and including at least one carbon-carbon double bond; wherein alkynyl refers to a hydrocarbon radical containing from 2 to 10 carbon atoms and including at least one carbon-carbon triple bond; wherein cycloalkyl refers to a non-aromatic mono or multicyclic ring system having 3 to 12 carbon atoms; wherein cycloalkenyl refers to a non-aromatic mono or multicyclic ring system having 3 to 12 carbon atoms and including at least one carbon-carbon double bond; wherein aryl refers to an aromatic radical having 6 to 14 carbon atoms, including monocyclic, bicyclic and tricyclic aromatic systems; "carbocyclic ring" refers to a saturated or unsaturated, 3- to 10-membered, saturated or unsaturated, monocyclic, fused bicyclic, spirocyclic or polycyclic ring containing carbon atoms; wherein "heterocyclic ring" or "heterocyclyl" refers to a substituted or unsubstituted non-aromatic 3- to 15-membered ring consisting of carbon atoms and with one or more heteroatoms independently selected from N, O or S; and wherein "heteroaryl" refers to a substituted or unsubstituted 5 to 14 membered aromatic heterocyclic ring, with one or more heteroatoms independently selected from N, O or S; or a pharmaceutically acceptable salt thereof or stereoisomers thereof. |
| priorityDate | 2010-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 540.