| abstract |
An in vitro method of inducing apoptosis in a target cell comprising the steps of: a. providing one or more target cells presenting the ICAM-1 cell surface antigen; b. providing one or more binding molecules that selectively bind to cell surface ICAM-1 and that, when binding to ICAM-1, induce apoptosis of the target cell; C. exposing the target cells of (a) to the binding molecules of (b) to induce apoptosis in the target cells; wherein the binding molecules are human antibody molecules, said antibody molecules having variable regions that have the sequences of Figure 10. |