http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2576871-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dded61bd89f99900518597c0958b9a9 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-88 |
| filingDate | 2011-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8594f544197afa061b4ef49731b1d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b81e4df56904c3417de12a0cd18ac14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e87ab0125fbb7f6d97e5d0066402da71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dd429b53fddb930beab3b5495f062e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_010369ac5bbca3696b5d631665adae05 |
| publicationDate | 2016-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2576871-T3 |
| titleOfInvention | Process and intermediates to prepare lapatinib |
| abstract | A process for preparing lapatinib or its pharmaceutically acceptable salt, comprising converting a compound of formula (IX) ** Formula ** to lapatinib or its pharmaceutically acceptable salt, wherein the step of converting the compound of formula (IX) to lapatinib or its pharmaceutically acceptable salt is made by method A or method B described below: method A comprising: i) activating the compound of formula (IX) with a halogenation, sulfonation, phosphonylation or amide bond reagent; ii) reacting the activated compound of formula (IX) with 3-chloro-4- (3-fluorobenzyloxy) aniline (VII) to produce the compound of formula (IV) ** Formula ** or its salt; and iii) converting the compound of formula (IV) or its salt to lapatinib or its pharmaceutically acceptable salt: method B comprising: i ') reacting the compound of formula (IX) with 2- (methylsulfonyl) ethanamine (VIII) or its salt to produce the compound of formula (XI): ** Formula ** ii ') activating the compound of formula (XI) with an activating agent to produce the compound of formula (XII): ** Formula ** wherein X 'is an outgoing group; and iii ') converting the compound of formula (XII) to lapatinib by reacting the compound of formula (XII) with the compound of formula (VII). |
| priorityDate | 2010-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 125.