http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2576182-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3f0e91e54aefb27b0f25cf3922d2e74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37d7602bda2969b4cb4532981659fff9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b399910f300dd02ff53340b6448cf604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a8ea2f23ab4914c7255e05c509ba79b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35768cc3ee303d73cd9beba17f12ebd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2f76a9bd1e9a5e70124483c5d5dff4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b717b4b9822cfcdf3967eabcd267135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_275ffef29403db7e19bd488792377d32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c3230e37da959e4d32f096005101178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a61045fdde70d96bd9778de3e49709 |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2576182-T3 |
| titleOfInvention | Novel heterocyclic derivatives and their use in the treatment of neurological disorders |
| abstract | A compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein X1 is CR1 or N; X3 is CR3 or N; X4 is CR4 or N; X5 is CR5; where one and no more than one of X1, X3 and X4 is N; R1 is hydrogen; R2 is an aryl, heteroaryl or non-aromatic heterocyclyl group G1, whose group G1 is optionally substituted by 1, 2, 3 or 4 substituents independently selected from the group, consisting of cyano, amino, amino (C1-8) alkyl, N -C 1-4 alkyl-C 1-8 alkyl, N, N-C 1-4 alkyl-amino C 1-8 alkyl, aminocarbonyl, thiocarbamoyl, halogen, C 1-8 alkyl, halogen (C1-8) alkyl, hydroxy, oxo, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, C1-8 alkylthio halogen, (C1-8) alkoxy (C1-8), (C3-8) cycloalkyl (C1-8) alkoxy, (C1-8) alkoxy (C1-8) alkoxy; (C1-8) alkoxy-(C1-8) alkylthio (C1-8) alkylthio (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), alkynyl (C2-8), alkenoxy (C2-8), alkyloxy (C2-8) and a cycloalkyl (C3-8), aryl, heteroaryl or non-aromatic heterocyclyl group G2, whose group G2 is optionally substituted by 1, 2, 3, or 4 substituents independently selected from the group, consisting of cyano, aminocarbonyl, halogen, (C 1-8) alkyl, halogen (C 1-8) alkyl, hydroxy, (C1-8) alkoxy, halogen (C1-8) alkoxy, (C1-8) alkylthio, halogen (C1-8) alkyl, (C1-8) alkoxy (C1-8) alkyl, (C1-) alkoxy 8) -alkoxy (C1-8), alkoxy (C1-8) -alkylthio (C1-8), alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8) ), (C1-8) alkylthio (C1-8) alkylthio (C2-8) alkenyl and (C2-8) alkynyl; R3 is hydrogen; R4 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C1-8), halogen-alkoxy (C1-8), alkylthio (C1-8), halogen-alkylthio (C1-8) a, (C1-8) alkoxy-(C1-8) alkyl, (C1-8) alkoxy-C1-8 alkoxy, (C1-8) alkoxy-(C1-8) alkylthio alkylthio (C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl (C2-8); R5 is hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, alkoxy (C1-8), halogen-C1-8 alkoxy, alkylthio (C1-8), halogen-alkylthio (C1-8), (C1-8) alkoxy-(C1-8) alkyl, (C1-8) alkoxy-(C1-8) alkoxy (C1-8) -alkylthio (C1-8), alkylthio ( C1-8) -alkyl (C1-8), alkylthio (C1-8) -alkoxy (C1-8), alkylthio (C1-8) -alkylthio (C1-8), alkenyl (C2-8), or alkynyl ( C2-8), or R4 and R5, taken together are -C (H)> = C (H) -C (H)> = C (H) - or an alkylene group (C1-8), in which 1 or 2 -CH2- ring members of the (C1-8) alkylene group are optionally replaced with hetero-ring members independently selected from the group consisting of -N (H) -, N [(C1-8) alkyl] -, -O -, - S-, -S (> = O) - or -S (> = O) 2-; R 6 is C 1-8 alkyl), halogen C 1-6 alkyl, hydroxy C 1-8 alkyl, C 1-8 alkoxy C 1-8 alkyl, mercapto C 1-8 alkyl , (C1-8) alkylthio (C1-8) alkyl, amino (C1-8) alkyl; N-C1-4 alkyl-amino-C1-8 alkyl, N, N-C1-4 dialkyl> = amino (C1-8) alkyl, (C2-8) alkenyl, or (C2-8) alkynyl ); R5 and R6, taken together, are an (C1-4) alkylene group, in which 1 -CH2- ring member of the (C1-4) alkylene group is optionally replaced with a hetero-ring member independently selected from the group, consisting of of N (H) -, -N [(C1-4) alkyl] -, -O-, -S-, - (> = O) - or -S (> = O) 2-; E1 is -C (R7) (R8) - where each of R7 and R8 is hydrogen; E2 is -C (R11) (R12) -; Any one of R11 and R12 is independently selected from the group, which consists of hydrogen, cyano, halogen, (C1-8) alkyl, halogen (C1-8) alkyl, (C1-8) alkoxy-(C1-8) alkyl ) and (C1-8) alkylthio (C1-8) alkyl; or R11 and R12, taken together, are oxo or -CR15R16-CR17R18- where R15, R16, R17 and R18 are independently selected from hydrogen and fluoro. |
| priorityDate | 2011-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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