| abstract |
A compound of Formula B: ** Formula ** wherein: R1 is -C (> = O) NHOH; X2 is a bond, -C1-C6-alkylene, -C2-C6-alkenylene, -C2-C6 -alkylene, -heteroalkylene-C1-C6-, fluoroalkylene-C1-C6, fluoroalkenylene-C2-C6, haloalkylene -C1-C6, haloalkenylene-C2-C6, alkylene-C1-C6- O-, -alkylene-C1-C3-O-alkylene-C1-C3-, -alkylene-C1-C6-NH-, -alkylene-C1 -C3-NH-alkylene-C1-C3-, - alkylene-C1-C6-C (> = O) NH-, -alkylene-C1-C3-C (> = O) NH-alkylene-C1-C3-, -C1-C6-NHC-alkylene (> = O) -, - C1-C3-NHC-alkylene (> = O) -C1-C3-alkylene-, -C1-C6-S- alkylene-C1-alkylene -C3-S-alkylene-C1-C3-, - alkylene-C1-C6-S (> = O) -, -alkylene-C1-C3-S (> = O) -alkylene-C1-C3-, -alkylene -C1-C6-S (> = O) 2-, -C1-C3-S-alkylene (> = O) 2-C1-C3-alkylene, -C (> = O) -, or -C (> = O) -C1-C6 alkylene; R2 is a substituted or unsubstituted group selected from aryl, heteroaryl, cycloalkyl-C3-C10, and heterocycloalkyl-C2-C10; where R2 is substituted, then R2 is substituted with 1, 2 or 3 groups selected from halogen, C1-C6 alkoxy, C1-C6 fluoroalkoxy, C1-C6 amino-alkoxy, C1-C3-aminoalkoxy alkyl C1-C3, hydroxy-C1-C3 alkyl-amino-C1-C3 alkoxy, heterocycloalkyl-C2-C8-C1-C3 alkoxy, heterocycloalkyl-C2-C8-C1-C2 alkyl, -CN, -NO2 , -CO2R10, -C (> = O) R11, -S-R11, -S (> = O) -R11, -S (> = O) 2-R11, - NR10C (> = O) -R11, - C (> = O) N (R10) 2, -S (> = O) 2N (R10) 2, -NR10S (> = O) 2-R11, OC (> = O) N (R10) 2, -NR10C (> = O) O-R11, - OC (> = O) O-R11, -NHC (> = O) NH-R11, -OC (> = O) -R11, -N (R10) 2, -alkyl -C1-C2-N (R10) 2, -C1-C6 alkyl, fluoroalkyl-C1-C6, alkenyl-C2-C6, alkynyl-C2-C6, heteroalkyl-C1-C6, cycloalkyl-C3-C8, heterocycloalkyl- C2-C10 substituted or unsubstituted, substituted or unsubstituted aryl, substituted or unsubstituted heteroryl; R 10 is hydrogen, or a substituted or unsubstituted group selected from C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 1 -C 6 heteroalkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 heterocycloalkyl, aryl and heteroaryl; R 11 is a substituted or unsubstituted group selected from C 1 -C 6 alkyl, C 1 -C 6 fluoroalkyl, C 3 -C 8 cycloalkyl, C 2 -C 8 heterocycloalkyl, aryl and heteroaryl; each R3 is independently hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C1-C6 alkoxy, fluoroalkoxy-C1- C6 substituted or unsubstituted, heteroalkyl-C1-C6 substituted or unsubstituted, substituted or unsubstituted phenyl, or aminoalkyl-C1-C6; or a pharmaceutically acceptable salt, pharmaceutically acceptable N-oxide, or pharmaceutically acceptable prodrug thereof. |