http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2575367-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bbe7bd4436431bfa83d0d0576c82562 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_499df856aacd97996fcd83b1653cbda0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ebb7ce3a15a74a64f831d47ef4882d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d2393da59d45c028cec2fa2ddc3011d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-22 |
| filingDate | 2012-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d9996c64f91db723c7ed1db136abe11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_950ae2eacf843d2e45a6e4809f1369f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_deca1eb21dc228d7b95fa584224ca92e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b75fd16ec91a776ca0951ebc22c98102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca5901c833f84f560f6bf5df3c255bf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6dfd4f3c211434b167e2315aa9ceebf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24867415bcfc6666dfffaa6f19c0aa55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a1a29933f19cc31e5984ebb7662959e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_405ceacf56bdd6d47aa4195a49f725f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4224e171623791b3cc1b1e109575a5a |
| publicationDate | 2016-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2575367-T3 |
| titleOfInvention | Carbonic anhydrase inhibitors and their production method |
| abstract | Compounds of general formula I ** Formula ** in which the substituent X can be independently selected from a group comprising BH, CH, BR1 and CR1, while simultaneously at most four X, preferably at most three X, can be CH or CR1 and while at least one BR1 or CR1 group is present; R1 in at least one substituent X is selected from a group comprising A-NHSO2NH2, A-SO2NH2 and AO-SO2NH2, and R1 in other substituents X can be independently selected from a group comprising A-NHSO2NH2, A-SO2NH2, A- OSO2NH2, C1-C8 alkyl, C2-C8 alkenyl, C6-C10 aryl, C2-C8 alkynyl, C4-C10 heteroaryl containing an O, S or N heteroatom, C1-C8 alkoxy, C1-C8 alkylhydroxy, C1-C8 alkylmercapto , OH, NH2, NH3 +, C1-C8 alkylammonium, C1-C8 alkylamino, halogen; A is selected from a group comprising a single bond or bivalent linear C1-C10 hydrocarbon chain, in which at least one carbon atom can be optionally substituted by heteroatoms selected from a group comprising N, S, O, or heteroarylene C4-C10, in which the heteroatom is selected from O, N and S; Y is MR2, or Y is not present; M is a metal of group VIB or VIIIB of the periodic table, preferably Cr, Fe, Ru or Co; R2 is selected from a group comprising a structure of general formula II ** Formula ** in which X is as defined above while simultaneously at most three X can be CH or CR1; R1 is independently selected from a group comprising AO-SO2NH2, A-SO2NH2, A-NHSO2NH2, C1-C8 alkyl, C2-C8 alkenyl, C6-C10 aryl, C2-C8 alkynyl, C4-C10 heteroaryl containing O, S or N as heteroatom, C1-C8 alkoxy, C1-C8 alkylhydroxy, C1-C8 alkylmercapto, OH, NH2, NH3 +, C1-C8 alkylammonium, C1-C8 alkylamino, halogen, and A is as described above, cyclopentadienyl with η5 bond, optionally substituted with 1 to 5 methyl, and phenyl ring with η6 bond, optionally bearing from 1 to 6 C1-C6 alkyl groups; Z is H or not present; while from one to three Z are H only when Y is not present; wherein alkyl indicates a linear or branched C1-C8 hydrocarbon moiety that does not comprise multiple bonds, which may be optionally substituted with one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2 , SH; alkenyl indicates a linear or branched C2-C8 hydrocarbon chain, comprising at least one double bond, which may be optionally substituted with one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2 , SH, SO3H; alkynyl indicates a linear or branched C2-C8 hydrocarbon chain, comprising at least one triple bond and optionally also at least one double bond, which may be optionally substituted with one or more substituents selected from a group comprising OH, halogen, NH2 , COOH, CONH2, CN, NO2, SH, SO3H; aryl indicates a C6-C10 aromatic carbocyclic group, which comprises at least one aromatic ring or condensed aromatic rings, which may be optionally substituted with one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; heteroaryl indicates a C4-C10 aromatic carbocyclic group, comprising at least one aromatic ring or condensed aromatic rings, in which at least one carbon atom is replaced by a heteroatom selected from a group comprising N, S, O, which may be optionally substituted with one or more substituents selected from a group comprising OH, halogen, NH2, COOH, CONH2, CN, NO2, SH, SO3H; alkoxy indicates a monovalent group derived from C1-C8 alcohol by separating a hydrogen atom from a hydroxyl group; alkylamino is a group created by substituting one or two hydrogen atoms of an amino group for C1-C8 alkyl; alkylmercapto is a monovalent group derived from thiol C1-C8 by cleavage of a hydrogen atom from a SH group; halogen is fluorine, chlorine, bromine or iodine atom; C1-C10 linear bivalent hydrocarbon chain refers to a chain containing single bonds, optionally also double bonds, which is linked by terminal carbons; and its pharmaceutically acceptable salts and solvates. |
| priorityDate | 2011-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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