http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2575143-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_331524805723a5a4cada42ce5fc156e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d014aeb4e5b4a9f9b707cc445d036ea |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2012-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e4ca2350e1ea3099af56b4786f89e37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34c919864bf08109bef676a7ae388000 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76e439b21a9025cdd882baafb5c87b50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ef8d5b75e0529fd081df543a613a174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a29c4529d507129115e71920e0952b31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e86e0378a90514253749c40cee04a68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc743c0189665862cf59dcf00a6ec5f8 |
| publicationDate | 2016-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2575143-T3 |
| titleOfInvention | Atypical protein kinase C thienopyridine inhibitors |
| abstract | A compound of formula (I) ** Formula ** or a salt form thereof, where A is NR11, O, or S; MQX is a group of the formula ** Formula ** G is a group of the formula ** Formula ** R1, R2, R11, and R17 are independently selected from H, C1-6alkyl optionally substituted with 1 to 13 R19, C2 - 6alkenyl optionally substituted with 1 to 11 R19, C2-6alkyl optionally substituted with 1-9 R19, C6-11aryl optionally substituted with 1 to 11 R19, C7-16arylalkyl optionally substituted with 1 to 19 R19, C3-11cycloalkyl optionally substituted with 1 at 21 R19, C4-17 cycloalkyl alkyl optionally substituted with 1 to 32 R19, 3-15 heterocycloalkyl members optionally substituted with 1-28 R19, 4-21 heterocycloalkylalkyl members optionally substituted by 1 to 40 R19, 5-15 membered heteroaryl optionally substituted by 1 to 15 R19, 6-21 heteroarylalkyl members optionally substituted by 1 to 27 R19, and -OR20; R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, R16, and R18 are independently selected from H, C1-6alkyl optionally substituted with 1 to 13 R19, C2-6alkenyl optionally substituted 1-11 R19, C2-6alkyl optionally substituted by 1-9 R19, C6-11aryl optionally substituted with 1 to 11 R19, C7-16arylalkyl optionally substituted with 1 to 19 R19, C3-11cycloalkyl optionally substituted with 1 to 21 R19, C4-17 cycloalkyl alkyl optionally substituted with 1 to 32 R19, 3-15 heterocycloalkyl members optionally substituted with 1 to 28 R19, 4-21 heterocycloalkylalkyl members optionally substituted with 1 to 40 R19, 5-15 membered heteroaryl optionally substituted with 1 to 15 R19 , 6-21 heteroaryloalkyl members optionally substituted by 1 to 27 R19, halogen, -CN, -C (> = O) R20, -C (> = O) OR20, -C (> = O) NR22R23, -C (> = O) C (> = O) R20, -C (> = NR25) R20, -C (> = NR25) NR22R23, -C (> = NOH) NR22R23, -C (> = NOR26) R20, -C ( > = NNR22R23) R20, - C (> = NNR24C (> = O) R21) R20, -C (> = NNR24C (> = O) OR2 1) R20, -C (> = S) NR22R23, -NC, -NO2, -NR22R23, -NR24NR22R23, -N> = NR24, -NR24OR26, -NR24C (> = O) R20, -NR24C (> = O) C (> = O) R20, -NR24C (> = O) OR21, -NR24C (> = O) C (> = O) OR21, -NR24C (> = O) NR22R23, -NR24C (> = O) NR24C ( > = O) R20, -NR24C (> = O) NR24C (> = O) OR20, -NR24C (> = NR25) NR22R23, -NR24C (> = O) C (> = O) NR22R23, -NR24C (> = S) R20, -NR24C (> = S) OR20, -NR24C (> = S) NR22R23, -NR24S (> = O) 2R21, -NR24S (> = O) 2NR22R23, -NR24P (> = O) R28R28, - NR24P (> = O) (NR22R23) (NR22R23), -NR24P (> = O) (OR20) (OR20), -NR24P (> = O) (SR20) (SR20), -OR20, -OCN, -OC ( > = O) R20, -OC (> = O) NR22R23, -OC (> = O) OR20, -OC (> = NR25) NR22R23, -OS (> = O) R20, -OS (> = O) 2R20 , -OS (> = O) 2OR20, - OS (> = O) 2NR22R23, -OP (> = O) R28R28, -OP (> = O) (NR22R23) (NR22R23), -OP (> = O) ( OR20) (OR20), - OP (> = O) (SR20) (SR20), -Si (R24) 3, -SCN, -S (> = O) NR20, -S (> = O) 2OR20, -SO3R27 , -S (> = O) 2NR22R23, -S (> = O) NR22R23, - P (> = O) R28R28, -SP (> = O) (NR22R23) (NR22R23), -SP (> = O) ( OR20) (OR20), -SP (> = O) (SR20) (SR20), - P (> = O) R28R28, -P (> = O) (NR22R23) (NR22R23), -P (> = O) (OR20) (OR20), and P (> = O) (SR20) (SR20); any of R1 and R2, R1 and R3, R1 and R5, R1 and R11, R4 and R1, R6 and R11, and R16 and R17 can, together with the atoms they bind, form a 3-15 membered heterocycloalkyl optionally substituted by 1-28 R19 or a 5-15 membered heteroaryl optionally substituted by 1 to 15 R19; any of R3 and R6, R7 and R8, R9 and R10, R12 and R13, and R14 and R15 can, together with the atoms that bind, form a C6-11aryl optionally substituted by 1 to 11 R19, C3-11cycloalkyl optionally substituted by 1-21 R19, 3-15 heterocycloalkyl members optionally substituted by 1 to 28 R19 or a 5- to 15-membered heteroaryl optionally substituted by 1 to 15 R19; R3 and R5 or R4 and R6 together can form a double bond; any of R3 and R4, and R5 and R6 together can form> = O,> = NR20,> = NOR20, or> = S; R19 at each occurrence is independently selected from C1-6alkyl optionally substituted with 1 to 13 R39, C2-6alkenyl optionally substituted with 1 to 11 R39, C2-6alkyl optionally substituted with 1-9 R39, C6-11aryl optionally substituted with 1 to 11 R39, C7-16 arylalkyl optionally substituted with 1 to 19 R39, C3-11cycloalkyl optionally substituted with 1 to 21 R39, C4-17cycloalkyl alkyl optionally substituted with 1 to 32 R39, 3-15 heterocycloalkyl members optionally substituted with 1 to 28 R39, 4- 21 heterocycloalkylalkyl members optionally substituted with 1 to 40 R39, 5-15 membered heteroaryl optionally substituted with 1 to 15 R39, 6-21 heteroarylalkyl members optionally substituted with 1 to 27 R39, halogen, -CN, -C (> = O) R30, -C (> = O) OR30, -C (> = O) NR32R33, -C (> = O) C (> = O) R30, -C (> = NR35) R30, -C (> = NR35 ) NR32R33, -C (> = NOH) NR32R33, -C (> = NOR36) R30, -C (> = NNR32R33) R30, -C (> = NNR34C (> = O) R31) R30, -C (> = NNR34C (> = O) OR31) R30, -C (> = S) NR32R33, -NC, -NO2, -N R32R33, -NR34NR32R33 -N> = NR34,> = NR30> = NOR30, -NR34OR36, -NR34C (> = O) R30, -NR34C (> = O) C (> = O) R30, -NR34C (> = O ) OR31, -NR34C (> = O) C (> = O) OR31, -NR34C (> = O) NR32R33, -NR34C (> = O) NR34C (> = O) R30, -NR34C (> = O) NR34C (> = O) OR30, -NR34C (> = NR35) NR32R33, -NR34C (> = O) C (> = O) NR32R33, -NR34C (> = S) R30, -NR34C (> = S) OR30, - NR34C (> = S) NR32R33, -NR34S (> = O) 2R31, -45 NR34S (> = O) 2NR32R33, -NR34P (> = O) R38R38, -NR34P (> = O) (NR32R33) (NR32R33), - NR34P (> = O) (OR30) (OR30), -NR34P (> = O) (SR30) (SR30), -OR30,> = O, -OCN, -OC (> = O) R30, -OC ( > = O) NR32R33, -OC (> = O) OR30, -OC (> = NR35) NR32R33, -OS (> = O) R30, -OS (> = O) 2R30, -OS (> = O) 2OR30 , -OS (> = O) 2NR32R33, -OP (> = O) R38R38, -OP (> = O) (NR32R33) (NR32R33), -OP (> = O) (OR30) (OR30), - OP ( > = O) (SR30) (SR30), -Si (R34) 3, -SCN,> = S, -S (> = O) NR30, -S (> = O) 2OR30, -SO3R37, -S (> = O) 2NR32R33, -S (> = O) NR32R33, -P (> = O) R38R38, SP (> = O) (NR32R33) (NR32R33), - SP (> = O) (OR30) (OR30), -SP (> = O) (SR30) (SR30), - P (> = O) R38R38, -P (> = O) (NR32R33) (NR32R33), -P (> = O) (OR30) (OR30) , and - P (> = O) (SR30) (SR30); R20, R21, R24, R25, R26, R27, R30, R31, R34, R35, R36 and R37 at each occurrence is independently selected from H, C1-6alkyl optionally substituted with 1 to 13 R49, C2-6alkenyl optionally substituted with 1 -11 R49, C2-6alkynyl optionally substituted with 1-9 R49, C6-11aryl optionally substituted with 1-11 R49, C7-6aryloalkyl optionally substituted with 1-19 R49, C3-1cycloalkyl optionally substituted with 1-21 R49, C4- 1-cycloalkyl alkyl optionally substituted by 1 to 32 R49, 3-15 heterocycloalkyl members optionally substituted by 1 to 28 R49, 4-21 heterocycloalkylalkyl members optionally substituted by 1 to 40 R49, 5-15 membered heteroaryl optionally substituted by 1 to 15 R49, and 6-21 heteroarylalkyl members optionally substituted by 1 to 27 R49; R28 and R38 at each occurrence is independently selected from C1-6alkyl optionally substituted with 1 to 13 R49, C2-6alkenyl optionally substituted with 1 to 11 R49, C2-6alkyl optionally substituted with 1-9 R49, C6-11aryl optionally substituted with 1 -11 R49, C7-16 arylalkyl optionally substituted with 1 to 19 R49, C3-11cycloalkyl optionally substituted with 1 to 21 R49, C4-1cycloalkyl alkyl optionally substituted with 1 to 32 R49, 3-15 heterocycloalkyl members optionally substituted with 1-28 R49, 4-21 heterocycloalkylalkyl members optionally substituted with 1 to 40 R49, 5-15 membered heteroaryl optionally substituted with 1 to 15 R49, and 6-21 heteroarylalkyl members optionally substituted with 1 to 27 R49, R22, R23 R32 and R33;, in Each occurrence is independently selected from H, C1-6alkyl optionally substituted with 1 to 13 R59, C2-6alkenyl optionally substituted with 1 to 11 R59, C2-6alkyl optionally substituted with 1-9 R59, C6-1 1 aryl optionally substituted with 1 to 11 R59, C7-16 arylalkyl optionally substituted with 1 to 19 R59, C3-11 cycloalkyl optionally substituted with 1 to 21 R59, C4-1 cycloalkyl alkyl optionally substituted with 1 to 32 R59, 3-15 heterocycloalkyl of optionally substituted with 1 to 28 R59, 4-21 heterocycloalkylalkyl members optionally substituted with 1 to 40 R59, 5-15 member heteroaryl optionally substituted with 1 to 15 R59, and 6-21 heteroarylalkyl members optionally substituted with 1 to 27 R59; or any R22 and R23 and / or R32 and R33 may form, together with the nitrogen atom to which they are attached, a 3-15 membered heterocycloalkyl optionally substituted by 1 to 28 R69 or a 5-15 member heteroaryl optionally substituted by 1 -15 R69; R39, R49, R59 and R69 at each occurrence is independently selected from C1-6alkyl optionally substituted with 1 to 13 R79, C2-6alkenyl optionally substituted with 1 to 11 R79, C2-6alkynyl optionally substituted with 1-9 R79, C6-11aryl optionally substituted with 1 to 11 R79, C7-16 arylalkyl optionally substituted with 1 to 19 R79, C3-11cycloalkyl optionally substituted with 1 to 21 R79, C4-17cycloalkyl alkyl optionally substituted with 1 to 32 R79, 3-15 heterocycloalkyl optionally substituted with 1 -28 R79, 4-21 hetero members optionally substituted by R79 1-40, 5-15 heteroaryl members optionally substituted by R79 1-15, 6-21 heteroarylalkyl members optionally substituted by 1-27 R79, halogen, -CN, -C (> = O) R70, -C (> = O) OR70, -C (> = O) NR72R73, -C (> = O) C (> = O) R70, -C (> = NR75) R70, - C (> = NR75) NR72R73, -C (> = NOH) NR72R73, -C (> = NOR76) R70, -C (> = NNR72R73) R70, -C (> = NNR74C (> = O) R71) R70, -C (> = NNR74C (> = O) OR71) R70, -C (> = S) NR72R73 -NC, -NO2, -NR72R73 -NR74NR 72R73 -N> = NR74> = NR70,> = NOR70, -NR74OR76, -NR74C (> = O) R70, -NR74C (> = O) C (> = O) R70, -NR74C (> = O) OR71, -NR74C (> = O) C (> = O) OR71, -NR74C (> = O) NR72R73, -NR74C (> = O) NR74C (> = O) R70, -NR74C (> = O) NR74C (> = O) OR70, -NR74C (> = NR75) NR72R73, -NR74C (> = O) C (> = O) NR72R73, -NR74C (> = S) R70, -NR74C (> = S) OR70, -NR74C (> = S) NR72R73, -NR74S (> = O) 2R71, -NR74S (> = O) 2NR72R73, -NR74P (> = O) R78R78, -NR74P (> = O) (NR72R73) (NR72R73), - NR74P (> = O) (OR70) (OR70), -NR74P (> = O) (SR70) (SR70), -OR70,> = O, -OCN, -OC (> = O) R70, -OC (> = O) NR72R73, -OC (> = O) OR70, -OC (> = NR70) NR72R73, -OS (> = O) R70, -OS (> = O) 2R70, -OS (> = O) 2OR70, -OS ( > = O) 2NR72R73, -OP (> = O) R78R78, -OP (> = O) (NR72R73) (NR72R73), -OP (> = O) (OR70) (OR70), - OP (> = O) (SR70) (SR70), -Si (R74) 3, -SCN,> = S, -S (> = O) NR70, -S (> = O) 2OR70, -SO3R77, -S (> = O) 2NR72R73 , -S (> = O) NR72R73, -P (> = O) R78R78, -SP (> |
| priorityDate | 2011-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 728.