abstract |
An isolated anti-Cadherin-17 antibody comprising: a CDR1 heavy chain variable region comprising SEQ ID NO: 4; a CDR2 heavy chain variable region comprising SEQ ID NO: 8; a heavy chain variable region CDR3 comprising SEQ ID NO: 17; a light chain variable region CDR1 comprising SEQ ID NO: 24; a CDR2 light chain variable region comprising SEQ ID NO: 30; and a CDR3 light chain variable region comprising SEQ ID NO: 34, optionally wherein any of SEQ ID NOs: 4, 8, 17, 24, 30 or 34 independently comprises one, two, three, four or five substitutions amino acid preservatives, where the antibody is capable of being internalized in a cell expressing Cadherina-17. |