http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2573287-T3

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grantDate 2016-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2573287-T3
titleOfInvention Procedure for the preparation of a mono-N-alkyl-piperazine
abstract Process for the preparation of a mono-N-alkyl-piperazine of Formula I ** Formula ** in which R1 means C1 to C5 alkyl or 2- (2-hydroxy-ethoxy) -ethyl by diethanolamine reaction (DEOA) of formula II ** Formula ** with a primary amine of formula H2N-R1 (III) in the presence of hydrogen and a supported catalyst containing metal, characterized in that the catalytically active mass of the catalyst before reduction with hydrogen contains compounds of aluminum, copper, nickel and cobalt containing oxygen and, in the range of 0.2 to 5.0% by weight, tin compounds containing oxygen, calculated as SnO and the reaction is carried out in the phase liquid at an absolute pressure in the range of 95 to 145 bar.
priorityDate 2012-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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