http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2572803-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da0ce34460c654b33b5d997a7a57ceb1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 |
| filingDate | 2011-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3701b6a9d36de5b19de86a3f58e4b10d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88a9883ac8f265f7e3fc94e2774b9d1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b398495bdac5ed97a48202aab1d7caf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0c8a330bbbff5fe8e8b115ff989e9fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_727f601c841a916443857e4f3a14f6d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76323755c5cd531951976efd1800b99d |
| publicationDate | 2016-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2572803-T3 |
| titleOfInvention | GCs stimulators |
| abstract | A compound according to Formula IA or IB, or a pharmaceutically acceptable salt thereof, ** Formula ** wherein the symbol with the surrounding letter 5 B represents ring B, and ring B is a phenyl or a heteroaryl ring of 6 members, containing 1 or 2 ring atoms of nitrogen; n is an integer selected from 0 to 3; each JB is independently selected from halogen, -CN, -NO2, a C1-6 aliphatic group, -ORB or a C3-8 cycloaliphatic group; wherein each said C1-6 aliphatic group and each said C3-8 cycloaliphatic group is optionally and independently substituted with up to 3 examples of R3; each RB is independently selected from hydrogen, a C1-6 aliphatic group or a C3-8 cycloaliphatic group; wherein each said C1-6 aliphatic group and each said C3-8 cycloaliphatic ring is optionally and independently substituted with up to 3 examples of R3; each R3 is independently selected from halogen, -CN, C1-4 alkyl, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl); X is selected from N, C-H or C, and is optionally substituted by JD when X is N or C; Ring D is the 6-member ring that has X in Formula IA or the 5-member ring that has Y in Formula IB; each Y is independently selected from C-H, C, N, O or S, and is optionally substituted by JD when Y is C or N; each of the bonds between two adjacent Y atoms or between adjacent Y and N in Formula IB is independently a single or double bond depending on whether Y is C, N, O or S; m is an integer selected from 0 to 3; each JD is a substituent on a carbon or nitrogen ring atom and is independently selected from halogen, -NO2, -ORD, -SRD, -C (O) RD, -C (O) ORD, -C (O) N ( RD) 2, -CN, -N (RD) 2, -N (Rd) C (O) RD, -N (Rd) C (O) ORD, -SO2RD, -SO2N (RD) 2, -N (Rd ) SO2RD, a C1-6 aliphatic group, - (C1-6 aliphatic) -RD, a C3-8 cycloaliphatic ring, a 6 to 10 membered aryl ring, a 4 to 8 membered heterocyclic ring or a 5 to 8 heteroaryl ring to 10 members; wherein each said 4 to 8-membered heterocyclic ring and each said 5 to 10-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 6 to 10 membered aryl ring, each said 4 to 8 membered heterocyclic ring and each said 5 to 10 membered heteroaryl ring is optionally and independently substituted with up to 3 examples of R5; each RD is independently selected from hydrogen, a C1-6 aliphatic group, - (C1-6 aliphatic) -Rf, a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-heteroaryl ring members; wherein each said 4- to 8-membered heterocyclic ring and each said 5- to 6-membered heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted with up to 3 examples of R5; each Rd is independently selected from hydrogen, a C1-6 aliphatic group, - (C1-6 aliphatic) -Rf, a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-heteroaryl ring members; wherein each said heterocyclic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted by up to 3 examples of R5; each Rf is independently selected from a C3-8 cycloaliphatic ring, a 4- to 8-membered heterocyclic ring, phenyl or a 5- to 6-membered heteroaryl ring; wherein each said heterocyclic ring and each said heteroaryl ring contains between 1 and 3 heteroatoms independently selected from O, N or S; and wherein each said C1-6 aliphatic group, each said C3-8 cycloaliphatic ring, each said 4 to 8 membered heterocyclic ring, each said phenyl and each said 5 to 6 membered heteroaryl ring is optionally and independently substituted by up to 3 examples of R5; alternatively, two examples of RD attached to the same JD nitrogen atom, together with said JD nitrogen atom, form a 4- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each heteroaryl ring 5-member said is optionally and independently substituted by up to 3 examples of R5; or alternatively, an example of RD attached to a carbon, oxygen or sulfur atom of JD and an example of Rd attached to a nitrogen atom of the same JD, together with said carbon, oxygen or sulfur and said nitrogen atom of that same JD, form a 4- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 4 to 8-membered heterocyclic ring and each said 5-membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S, and wherein each said 4 to 8-membered heterocyclic ring and each heteroaryl ring 5-member said is optionally and independently substituted by up to 3 examples of R5; each R5 is independently selected from halogen, -CN, -NO2, C1-4 alkyl, a C7-12 aralkyl, C3-8 cycloalkyl ring, C1-4 haloalkyl, C1-4 cyanoalkyl, -OR6, -SR6, -COR6, -C (O) OR6, -C (O) N (R6) 2, -N (R6) C (O) R6, -N (R6) 2, -SO2R6, -SO2N (R6) 2, -N (R6 ) SO2R6, phenyl or an oxo group; wherein each said phenyl group is optionally and independently substituted with up to 3 examples of halogen, -OH, -NH2, -NH (C1-4 alkyl), -N (C1-4 alkyl) 2, -NO2, -CN, alkyl C1-4, C1-4 haloalkyl, -O (C1-4 alkyl) or -O (C1-4 haloalkyl); and wherein each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; each R6 is independently selected from hydrogen, a C1-4 alkyl, phenyl, a C7-12 aralkyl or a C3-8 cycloalkyl ring; wherein each of said C1-4 alkyl, each said phenyl, each said C7-12 aralkyl and each said cycloalkyl group is optionally and independently substituted with up to 3 examples of halogen; alternatively, two examples of R6 attached to the same nitrogen atom of R5, together with said nitrogen atom of R5, form a 5- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5 to 8 membered heterocyclic ring and each said 5 membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; or alternatively, an example of R6 attached to a nitrogen atom of R5 and an example of R6 attached to a carbon or sulfur atom of the same R5, together with said nitrogen and said carbon or sulfur atom of the same R5, form a 5- to 8-membered heterocyclic ring or a 5-membered heteroaryl ring; wherein each said 5 to 8 membered heterocyclic ring and each said 5 membered heteroaryl ring optionally contains up to 2 additional heteroatoms independently selected from N, O or S; or, alternatively, two JD groups attached to two neighboring D-ring atoms, taken together with said two neighboring D-ring atoms, form a 5- to 7-membered heterocycle resulting in a condensed D-ring wherein said 5 to 7 heterocycle members contain 1 to 3 heteroatoms independently selected from N, O or S; and wherein said 5- to 7-membered heterocycle is optionally and independently substituted by up to 3 examples of halogen, -OH, -NH2, -NH (C1-4 alkyl), -N (C1-4 alkyl) 2, -CN, C1-4 alkyl, C1-4 haloalkyl, -O (C1-4 alkyl), -O (C1-4 haloalkyl) or oxo; RC is selected from halo, -CN. |
| priorityDate | 2010-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1009.