abstract |
A compound of Formula (I): ** Formula ** wherein R 1 is C 1 -C 6 alkyl, C 3 -C 7 cycloalkyl, aryl or heteroaryl, wherein said aryl and heteroaryl can be substituted with one to three groups selected from the group consisting of acyl, C1-C6 alkyl, alkylsulfonyl, alkoxy, alkoxycarbonyl, cyano, halo, urea, amide, hydroxyl, SF5, oxo and nitro; R2 is selected from the group consisting of H, C1-C6 alkyl, alkoxy, cyano, halo, urea, amide, hydroxyl, oxo and nitro; R4 is CH2COOH, COOH, ester or amide; R5 is hydrogen, hydroxyl or oxo; each R7 is independently H or C1-C3 alkyl; each X is independently C or N, with the proviso that at least two X are C; Y is N or CR3, where R3 is H, C1-C6 alkyl, hydroxyl, halo, or alkoxy, wherein said C1-C6 alkyl can be further substituted with one to three groups selected from halo, hydroxyl, alkoxy, COOH and ester ; m is 0-3; n is 0-1, with the proviso that when n is 0, Y is CR3; or a pharmaceutically acceptable salt thereof. |