| abstract |
A pyridopyrimidine or pyrimidopyrimidine compound represented by formula (Ia), isomer, pharmaceutically acceptable salt, ester, prodrug, or solvate thereof: wherein R1 and R2 are each independently 3-oxa-8-azabicyclo[ 3.2.1]octanyl, 8-oxa-3-azabicyclo[3.2.1]octanyl, or NRARB, and at least one of R1 and R2 is 3-10 oxa-8-azabicyclo[3.2.1]octanyl or 8-oxa -3-azabicyclo[3.2.1]octanyl; where, RA and RB are each independently H, C1-C6 alkyl unsubstituted or substituted with C1-C6 alkoxy or halogen, or C1-C6 alkoxy unsubstituted or substituted with halogen, or RA and RB, together with the N to which are linked, they form a saturated nitrogen-containing heterocycle having 4 to 8 ring atoms that is unsubstituted or substituted with C1-C6 alkyl, C1-C6 alkoxy or halogen, the saturated nitrogen-containing heterocycle is a piperidine ring, morpholine ring, piperazine ring, N-methylpiperazine ring, homomorpholine ring, homopiperazine ring; and R3 is phenyl or pyridyl unsubstituted or substituted with 1 to 5 substituents, where the substituent is halogen; hydroxyl; cyan; C1-C7 alkyl unsubstituted or substituted with C1-C7 alkoxy, halogen or hydroxy; C1-C7 alkoxy; -NHS(>=O)2C1-C7alkyl; -NH2; C5-C6 arylamino; C1-C7 alkylamino; di(C1-C7 alkyl)amino; -C(O)NH2; or -C(O)NHC1-C3alkyl. |