| abstract |
Pharmaceutical composition containing as active ingredient a compound of formula (I): ** Formula ** (in which, RC and RD taken together with neighboring carbon atoms form a ring which may be a fused ring; Y is hydroxyl , mercapto or amino; Z is O, S or NH; RA is a group shown by (in which, ring C is an aromatic heterocycle containing N, in which at least one atom is next to the atom in the position of union is an unsubstituted N atom; the broken line shows the presence or absence of a bond) or by (where X is O, S or NH; RB is a substituent selected from the substitution group A); at least one of the ring formed by RC and RD, ring C or RB is substituted with a group of -Z1-Z2-Z3-R1 (in which Z1 and Z3 are each independently a bond, optionally substituted alkylene or optionally substituted alkenylene; Z2 is a bond, optionally substituted alkylene, optionally substituted alkenylene, -CH (OH) -, -S- , -SO-, -SO2-, - SO2NR2-, -NR2SO2-, -O-, NR2-, -NR2CO-, -CONR2-, -C (> = O) -O-, -OC (> = O) or -CO-; R2 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, or optionally substituted heteroaryl; R1 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, or optionally substituted heterocycle); the ring formed by RC and RD, ring C or RB is optionally substituted with a substituent that does not interfere in any position other than that in which the group of Z1-Z2-Z3-R1 is located (where Z1, Z2 , Z3 and R1 are the same as defined above); the substitution group A consists of: hydrogen, halogen, alkoxycarbonyl, carboxyl, alkyl, alkoxy, alkoxyalkyl, nitrile, hydroxyl, aralkyl, alkenyl, alkynyl, alkylsulfosyl, optionally substituted amino, alkylthiol, alkylthioalkyl, haloalkoxy, haloalkoxy, haloalkoxy, haloalkoxy substituted, optionally substituted cycloalkenyl, optionally substituted heterocycle, nitroso, azide, amidino, guanidino, cyano, isocyano, mercapto, carbamoyl optionally substituted, sulfamoyl optionally, formyl sulfoamino, alkylcarbonyl, optionally substituted alkylcarbonyloxy, hydrazino, morpholino, aryl , optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted oxaryl, optionally substituted oxyheteroaryl, optionally substituted thioaryl, optionally substituted thioheteroaryl, optionally substituted oxyaralkyl, oxyheteroalkylalkyl or optionally substituted, optionally substituted thioaralkyl, optionally substituted thioalkyl heteroaryl, optionally substituted oxyalkylaryl, optionally substituted oxyalkylheteroaryl, optionally substituted thioalkylaryl, optionally substituted thioalkyl, optionally substituted sulfonylaryl, sulfonylheteroaryl. |