| abstract |
A conjugate having a formula (hapten) m- (connector) '' - (reactive group) 0- (vehicle) p where: the hapten is an oxazole; The connector, to bind a hapten to a reactive group, is a polymer containing between 1 and 15 units of ethylene glycol; The reactive group, to attach a connector to a vehicle, is selected from the group consisting of an amine reactive group selected from the group consisting of an isothiocyanate, an isocyanate, an acyl azide, an NHS ester, an acid chloride, an aldehyde, a gioxal, an epoxy, an oxirane, a carbonate, an arylating agent, an imidoester, a carbodiimide, an anhydride and combinations thereof; a thiol reactive functional group is selected from the group consisting of a haloacetyl, an alkyl halide, a maleimide, an aziridine, an acryloyl derivative, an arylating agent; a 1-disulfide exchange reagent selected from the group consisting of pyridi-disulfide, a TNB thiol, a disulfide reducer and combinations thereof; carboxylate reactive functional groups selected from the group consisting of diazoalkane, a diazoacetyl compound, a carbonyldiimidazole compound and a carbodiimide; the hydroxyl-reactive functional groups selected from the group consisting of an ester, an orixano, a carbonyldiimidazole, an N, N'-disuccinimidyl carbonate, an N-hydroxysuccinimidyl chloroformate, an oxidizing compound of periodate, an alkyl halogen and an isocyanate; Aldehyde and ketone reactive functional groups selected from the group consisting of a hydrazine, a Schiff base, a reducing amine ion product, a Marmich condensation product, and combinations thereof; a hydrogen reactive active compound selected from the group consisting of a diazonium derivative, a Mannich condensation product, an iodination reaction product, and combinations thereof; a photoreactive chemical functional group selected from the group consisting of an aryl azide, a halogenated aryl azide, a benzophone, a diazo compound, a diazirine derivative and combinations thereof; The vehicle is selected from the group consisting of an amino acid, a polypeptide, a protein, a nucleoside, a nucleotide, a nucleotide chain, a nucleic acid, DNA, RNA, mRNA, a polymer, aminoalkyl agarose, aminopropyl crystal and dextran. crosslinked; m, n, o and p are 1. |