http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2569712-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d9af4d89807e0db8298692dffeabf875 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-536 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate | 2011-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec5f6bae763c7d340f4a7e845fadab44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e2d8db9514ade6625798c5d8fe2d4d2 |
| publicationDate | 2016-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2569712-T3 |
| titleOfInvention | PKM2 bicyclic activators |
| abstract | Compound of formula (Ia) or pharmaceutically acceptable salt thereof, in which: X and Y are each independently selected from O and N (-L-R1); each L is independently selected from a link, -C (O) -, - (CRaRb) m-, -C (5 O) N (Rc) - or -C (O) O-; A is aryl or heteroaryl, each of which is substituted with 0-3 occurrences of Rd; each R1 is independently selected from hydrogen, C1-4 alkyl, C1-4 haloalkyl, C3-10 alkyl-O-alkylene, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl and heterocyclyl alkyl; in which each alkyl-O-alkylene, cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl and heterocyclylalkyl is substituted with 0-3 occurrences of Rf and each alkyl and haloalkyl is substituted with 0-3 occurrences of Rg; each Ra and each Rb are independently selected from hydrogen, C1-4 alkyl, or Ra and Rb attached to the same carbon atom are taken together with the carbon atom to form a cycloalkyl; each Rc is independently selected from hydrogen and C1-4 alkyl; each Rd is independently selected from halo, C1-4 haloalkyl, C1-4 alkyl, nitro, cyano, -OH and -O (C1-4 alkyl), or two Rd, attached to the same carbon atoms or adjacent carbon atoms , taken together with the atom (s) to which they are attached form an optionally substituted heterocyclyl; each Rf is independently selected from halo, C1-4 haloalkyl, C1-4 alkyl, nitro, cyano, -OH and -O (C1-4 alkyl), or two Rf, attached to the same carbon atoms or adjacent carbon atoms , taken together with the atoms to which they are attached form an optionally substituted heterocyclyl; each Rg is independently selected from nitro, cyano, -OH and -O (C1-4 alkyl) or two Rg, attached to the same carbon atoms or adjacent carbon atoms, taken together with the atoms to which they are attached form a optionally substituted heterocyclyl; each R2 is independently selected from halo, C1-4 haloalkyl, C1-4 alkyl, C1-4 alkoxy and hydroxyl; h is 1, 2 or 3; each m is independently 1, 2 or 3; and each n is independently 0, 1, 2 or 3; provided that the compound is not 2-chloro-N- (1,4-dihydro-2-oxo-2H-3,1-benzoxazin-7-yl) -5 - [[(1-methylethyl) amino] sulfonyl] - benzamide; 4- [2-Oxo-7- (phenylmethoxy) -2H-1,3-benzoxazin-3 (4H) -yl] -benzoic acid methyl ester; 2-Chloro-5 - [[(1-methylethyl) amino] sulfonyl] -N- (1,2,3,4-tetrahydro-2-oxo-7-quinazolinyl) -benzamide; or 2-Chloro-5 - [[(1-methylethyl) amino] sulfonyl] -N- (1,2,3,4-tetrahydro-3-methyl-2-oxo-7-quinazolinyl) -benzamide; in which "heteroaryl" refers to a 5-8 membered monocyclic ring system, 8-12 membered bicyclic or 11-14 membered fully aromatic tricyclic having 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if it is bicyclic or 1-9 heteroatoms if it is tricyclic, said heteroatoms being selected from O, N or S; and "heterocyclyl" refers to a 3-10 membered monocyclic, 8-12 membered bicyclic or 11-14 membered tricyclic ring system having 1-3 heteroatoms if monocyclic, 1-6 heteroatoms if bicyclic or 1- 9 heteroatoms if it is tricyclic, said heteroatoms of O, N or S. being selected. |
| priorityDate | 2010-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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