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filingDate 2007-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61d7ad6eacf239e1fdede8920cf6fc2a
publicationDate 2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber ES-2568660-T3
titleOfInvention Production method of hyaluronic acid derivatives
abstract Method of producing a polysaccharide derivative comprising a polysaccharide having a carboxyl group attached to an organic compound having a functional group that can be fused to the carboxyl group, which comprises allowing the polysaccharide to react with the organic compound through the use of 4- (4,6-Dimethoxy-1,3,5-triazin-2-yl) -4-methylmorpholinium chloride, in which the polysaccharide having a carboxyl group is a hyaluronic acid having a weight average molecular weight 100,000 to 5,000,000 in which the degree of substitution of the organic compound is in the range of 5 to 20% as determined by calculations based on the amount of hyaluronic acid determined by the reaction of carbazole-sulfuric acid and the amount of the organic compound as determined by spectrophotometry, and wherein the organic compound is a compound obtained by covalently binding a photoreactive compound or a non-steroidal anti-inflammatory drug (NSAID) to a spacer substance, in which the spacer substance has the following formula: H2N - (CH2) n-OH in which n represents an integer from 2 to 18.
priorityDate 2006-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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