http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2567753-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52aa36aba8cab88933d1896ade475631 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2010-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_126824b6132dfc94d2307325d38ce334 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86661e3d1ee51d48b35cfd0bc1ab8133 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2c7f4f06a34a9abbe74d7b5767a7447 |
| publicationDate | 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2567753-T3 |
| titleOfInvention | Derivatives of 1,2,4-thiazolidin-3-one and their use in the treatment of cancer |
| abstract | A compound of formula I, ** Formula ** in which: A represents C (> = N-W-D) or S; B represents S or C (-NH-W-D); when: A represents C (> = N-W-D) and B represents S, then the dashed line between B and the N atom is a single bond; or A represents S and B represents C (-NH-W-D), then the broken line between B and the N atom is a double bond; X represents -Q- [CRxRy] n-; W represents- [CRxRy] m- or -C (O) - [CRxRy] p-; Q represents a bond, -N (Ra) -, -S- or -O-; A1 to A5 respectively represent C (R1), C (R2), C (R3), C (R4) and C (R5), or, alternatively, up to two of A1 to A5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted with one or more R6 groups; Rx and Ry, each time used herein, are independently selected from H, halogen, C1-6 alkyl (optionally substituted with one or more halogen atoms), aryl (optionally substituted with one or more halogen atoms ) or Rx and Ry are linked to form, together with the carbon atom to which they are attached, a 3 to 8 membered non-aromatic ring, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is the same optionally substituted with one or more substituents selected from halogen or C1-6 alkyl (optionally substituted with one or more halogen atoms); R1 to R5 independently represent H, halogen, -R7, -CF3, -CN, -NO2, -C (O) R7, -C (O) OR7, -C (O) - N (R7a) R7b, -N ( R7a) R7b, -N (R7) 3 +, -SR7, -OR7, -NH (O) R7, -SO3R7, aryl or heteroaryl (these same aryl and heteroaryl groups are optionally and independently substituted with one or more groups selected from halogen and R16), or any two of R1 to R5 that are adjacent to each other, are optionally linked to form, together with two atoms of the essential benzene ring in the compound of formula I, an aromatic or non-aromatic ring from 3 to 8 members, optionally containing 1 to 3 heteroatoms selected from O, S and N, the ring itself optionally substituted with one or more substituents selected from halogen, -R7, -OR7 and> = O; R6 independently represents, at each occurrence used herein, cyano, -NO2, halogen, -R16, -OR8, -N (R8) C (O) R8, -NR9R10, -SR11, -Si (R12) 3, -OC (O) R13, -C (O) OR13, -C (O) R14, -C (O) NR15aR15b, -S (O) 2NR15cR15d, aryl or heteroaryl (these same aryl and heteroaryl groups are optional and independently substituted with one or more groups selected from halogen and R16), or any two R6 groups that are adjacent to each other, are linked to form, together with two atoms of the essential benzene ring in the compound of formula I, an aromatic ring or 3 to 8 membered non-aromatic, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted with one or more substituents selected from halogen, -R7, -OR7 and> = O; R7, each time used herein, is selected from H or C1-C6 alkyl, C1-C6 cycloalkyl, aryl, and heteroaryl (wherein the last four groups are optionally substituted with one or more halogen atoms); R7a and R7b are independently selected from H, or C1-C6 alkyl, C1-C6 cycloalkyl, aryl and heteroaryl, or R7a and R7b are optionally linked to form, together with the nitrogen atom to which they are attached, an aromatic or non-aromatic ring 3 to 8 membered aromatic, optionally containing 1 to 3 heteroatoms selected from O, S and N, which ring is itself optionally substituted with one or more substituents selected from halogen, -R7, -OR7 and> = O; Ra, R8, R9, R10, R11, R12, R13, R14, R15a, R15b, R15c, and R15d, each time used herein, independently represent H or R16; R16 represents, on each occasion used herein, C1-6 alkyl optionally substituted with one or more halogen atoms; n represents 1 or 2; |
| priorityDate | 2009-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 627.