| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd43e12353298376fd7642260c1dbca |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0007
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2004-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bc7176f38dccc967d238d7cab155dec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f4158758409308ac932b330a3380451
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4462a735458cdf81e0f0f3aca50dfbb8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7da8fc9011bcb4385bc532ac98b1834a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24ed6074c50d51c76c77c9eac1067a93 |
| publicationDate |
2016-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2567437-T3 |
| titleOfInvention |
Beta- (1.42) amyloid oligomers, derivatives thereof and antibodies thereto, methods for preparing them and using them |
| abstract |
Oligomer of the β-1-42 truncated N-terminally soluble amyloid in physiological saline as opposed to rather globular fibrillar forms comprising fragments of Aβ (X-42), in which X represents a number from 10 to 24, the oligomer can be achieved according to a method comprising: (a) the detergent can act on a monomeric amyloid β (1-42) protein to form an Aβ oligomer (1-42) soluble in rather globular physiological saline solution unlike fibrillar forms; (b) the effect of the detergent is reduced and oligomer A of Aβ (1-42) is re-incubated to form an oligomer B of Aβ (1-42) soluble in physiological saline rather globular unlike forms fibrillar; and (c) oligomer B of Aβ (1-42) is treated with protease, the detergent being a compound of the formula RX, wherein the moiety R optionally represents branched alkyl with 6 to 20 carbon atoms or optionally alkenyl branched with 6 to 20 carbon atoms, and the remainder X represents an acidic group or its salt, and the oligomer B of Aβ (1-42) having an apparent molecular weight in the SDS gel electrophoresis of approximately 38 kDa and / or approximately 48 kDa. |
| priorityDate |
2003-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |