http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2567172-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d7f4098271cd640cd32d0ed724741f1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-34 |
| filingDate | 2007-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8d91e965185c3cb3bcc519dbc48befb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34b3c910d8cc50527b131f91c74006ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d6969c1d5b94170863058fe42a15ae7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81d81bc2307061275bc6a3022ef61f58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3308b062b78f903b39865b6b3121e062 |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2567172-T3 |
| titleOfInvention | Enantiomeric resolution process of d, l - (+) - treo-methylphenidate |
| abstract | Process for isolating the d- or l-threo isomer of methylphenidate hydrochloride comprising the steps of: (i) Resolution of a mixture comprising the racemic threomethylphenidate hydrochloride; less than or equal to 1.0 molar equivalents (based on the amount of racemic threo-methylphenidate hydrochloride) of chiral acid selected from one or more di-O, O'-aroyl tartaric acids, greater than or equal to 0.5 to 0.60 molar equivalents (based on the amount of racemic threo-methylphenidate hydrochloride) of one or more tertiary amine bases, and a solvent mixture consisting of one or more lower alkanols and water, allowing the formation of a salt of chiral acid-isomeric methylphenidate (ii) Basification of the chiral acid-isomeric methylphenidate salt to obtain the free base of isomeric methylphenidate and (iii) Conversion of the free base of isomeric methylphenidate into isomeric methylphenidate hydrochloride having a higher enantiomeric excess 90% and greater than 35% yield based on racemic treomethylphenidate hydrochloride. |
| priorityDate | 2007-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.