http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2567134-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ec699c96c809fdf202410d55b5cd797 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-00 |
| filingDate | 2010-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91538de36eac2c4728fc469e02b211c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88415697bb866d7c1d10896504755447 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5019d6903848821254acbda8f1ac7de5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_484cd93691d593a6b604cf8d47801d5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04efc9ede6b84f617cd7394722f824d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0515c812c8d8acbd360bfb814694836d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fd93285c939a7d3e4636c1a29838a79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3dd3e83c0f083a5c26f1ffc068b04fb |
| publicationDate | 2016-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2567134-T3 |
| titleOfInvention | Enzymatic transamination of cyclopamine analogs |
| abstract | A process for preparing a compound of the formula (II): ** Formula ** or a salt thereof; of a compound of the formula (I): ** Formula ** or a salt thereof; wherein: R1 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, haloalkyl, -OR16, -C (O) R16, -CO2R16, -SO2R16, - C (O) N ( R17) (R17), - [C (R16) 2] q-R16, - [(W) -N (R17) C (O)] qR16, - [(W) -C (O)] qR16, - [ (W) - C (O) O] qR16, - [(W) -OC (O)] qR16, - [(W) -SO2] qR16, - [(W) -N (R17) SO2] qR16, - [(W) -C (O) N (R17)] qR17, - [(W) -O] qR16, - [(W) - N (R17)] qR16, or - [(W) -S] qR16; where W is a dirradical and q is 1, 2, 3, 4, 5, or 6; each R2 and R3 is independently H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, haloalkyl, halo, -OR16, -OR16, -N (R17) 2, or -SR16, or R2 and R3 taken together form a double bond or form a group ** Formula ** where Z is NR17, O, or C (R18) 2; R4 is independently H, halo, -OR16, -N (R17) 2, or -SR16; each R5 and R6 is, independently, H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, halo, -OR16, -N (R17) 2, or -SR16; or R5 and R6 taken together with the carbon to which they bind form C> = O, C> = S, C> = N-OR17, C> = N-R17, C> = NN (R17) 2, or form a optionally substituted 3-8 member ring; Each R7, R8, R9, R10, R11, R12 and R13 is independently H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, halo, -OR16, -N (R17) 2, or -SR16; or R10 and R11 taken together, or R11 and R12 taken together, form a double bond or form a group ** Formula ** where Z is NR17, O, or C (R18)) 2; each R14 and R15 is, independently, H, halo, -OR16, -N (R17) 2, or -SR16; or R14 and R15 taken together with the carbon to which they bind form C> = O or C> = S; X is a bond or the group -C (R19) 2-; wherein each R19 is independently H, alkyl, aralkyl, halo, -CN, -OR16, or -N (R17) 2; R16 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl or - [C (R20) 2] p-R21 wherein p is 0-6; or any two occurrences of R16 in the same substituent are taken together to form an optionally substituted 4-8 membered ring; R17 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, -C (> = O) R20, - C (> = O) OR20, -SO2R20, -C (> = O) N (R20) 2, or - [C (R20)) 2] p-R21 where p is 0-6; or any two occurrences of R17 in the same substituent are taken together to form an optionally substituted 4-8 membered ring; R18 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl, halo, -CN, -OR20, -OSi (R20) 3, -C (> = O) R20, -C (> = O) OR20, -SO2R20 or -C (> = O) N (R20) 2; R20 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, or heteroaralkyl; or any two occurrences of R20 in the same substituent are taken together to form an optionally substituted 4-8 membered ring; R21 is -OR22, -N (R22) C (> = O) R22, -N (R22) C (> = O) OR22, -N (R22) SO2 (R22), - C (> = O) R22N ( R22) 2, -OC (> = O) R22N (R22) (R22), - SO2N (R22) (R22), -N (R22) (R22), -C (> = O) OR22, -C (> = O) N (OH) (R22), -OS (O) 2OR22, -S (O) 2OR22, -OP (> = O) (OR22) (OR22), - N (R22) P (O) (OR22 ) (OR22), or -P (> = O) (OR22) (OR22); and R22 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, aralkyl, heteroaryl, heteroaralkyl; or any two occurrences of R22 in the same substituent are taken together to form an optionally substituted 4-8 membered ring; said process comprises contacting a compound of the formula (I) or a salt thereof, an amino donor molecule, and an omega amine transaminase enzyme in a solution to provide a compound of the formula (II) or a salt thereof , wherein the alkyl is a saturated straight or branched chain hydrocarbon radical containing between one and thirty carbon atoms, the alkenyl is a straight or branched chain hydrocarbon radical having at least one carbon-carbon double bond by removing a single hydrogen atom, and containing between two and thirty carbon atoms, the alkynyl is a straight or branched chain hydrocarbon radical that has at least one carbon-carbon triple bond by removing a single hydrogen atom, and containing between two and thirty carbon atoms, the cycloalkyl is a saturated monocyclic or bicyclic hydrocarbon ring system having 3-15 ring members. carbon, the aryl is an aromatic monocyclic or bicyclic hydrocarbon ring system having a total of 6-10 members of the carbon ring, the aralkyl is an alkyl group substituted by an aryl group, where the point of attachment is at the alkyl group, is an aromatic monocyclic or bicyclic hydrocarbon ring system having 5-10 ring atoms wherein the ring atoms comprise, in addition to the carbon atoms, one to five heteroatoms, the heteroaralkyl is a substituted alkyl group by a heteroaryl group, wherein the point of attachment is in the alkyl group and the heterocycloalkyl or heterocyclyl is a stable non-aromatic 5-7 membered monocyclic hydrocarbon or stable non-aromatic 7-10 membered bicyclic hydrocarbon which is either saturated or partially unsaturated, and having, in addition to the carbon atoms, one or more heteroatoms, which are optionally substituted with one or more substituents. |
| priorityDate | 2009-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 717.