http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2566828-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c13193fe65025a46525ac2b48f75f12a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 |
| filingDate | 2011-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_866e1b213c19ecc61fbf0a691a3478a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98f9cd6e70ced01595764be814d6ca14 |
| publicationDate | 2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2566828-T3 |
| titleOfInvention | Buprenorphine analogs as agonists and / or opioid receptor antagonists |
| abstract | A compound of Formula I: ** Formula ** in which R1 is selected from hydrogen, -alkyl- (C1-C10), alkenyl- (C2-C12), alkynyl- (C2-C12), alkoxy- (C1- C10), cycloalkyl- (C3-C12), (cycloalkyl (C3-C12)) - alkyl- (C1-C6), heteroaryl- (5 to 12 members) and (heteroaryl (10 to 12 members)) - alkyl - (C1-C6); any of which is optionally substituted with 1, 2, or 3 substituents that are independently selected from the group consisting of alkyl- (C1-C6), -COOR7 and -CONR9R10; R2 and R8 are each independently hydrogen, alkyl- (C1-C10), alkynyl- (C2-C12), alkoxy- (C1-C10), - (OCH2CH2) s-Oalkyl (C1-C6), - (CH2CH2O) s-(C1-C6) alkyl, -NH2, -NH (C1-C6) alkyl, -CONR5R6, alkyl- (C1-C6) -CO-NR5R6, -COOR7, alkyl- (C1-C6) -CO-OR7, cycloalkyl- (C3-C12), aryl- (5 to 12 members), (aryl (5 to 12 members)) - alkyl- (C1-C6), heteroaryl- (5 to 12 members), bicycloheterocycle- ( 7 to 12 members), phenyl, benzyl or naphthyl; each of which is optionally substituted with one or two substituents that are independently selected from the group consisting of -OH, halo, -C (halo) 3, -CH (halo) 2, - CH2 (halo), alkyl- ( C1-C6), alkenyl- (C2-C6), alkynyl- (C2-C6), hydroxyalkyl- (C1-C6), dihydroxyalkyl- (C1-C6), alkoxy- (C1-C6), (alkoxy (C1- C6)) CO-C1-C6 alkoxy, phenyl, benzyl, -NH2, -CN, -OR4, -CONR5R6, - (C1-C6 alkyl) -CO-NR5R6, -COOR7, alkyl- (C1-C6) - CO-OR7, alkoxy- (C1-C6) -COOR7, - (OCH2CH2) s-Oalkyl (C1-C6), -NH-SO2alkyl (C1-C6), -N (SO2alkyl (C1-C6)) 2, - C (> = NH) NH2, -NH-CO-(C1-C6) alkyl, -NH-CO-NH2, - NH-C (> = O) -NH-(C1-C6) alkyl, -NH-C (> = O) aryl- (5 to 12 members), -NH-(C1-C6) alkyl -CO-OR7, -NH-C (> = O) - (C1-C6) alkyl -CO-OR7, aryl- (5 to 12 members), -NH-(C1-C6) alkyl -C (O) -NR5R6, -C (O) NH-alkyl (C1-C6) - COOR7, heteroaryl- (5 to 12 members) and (heteroaryl (5 to 12 members)) - (C1-C6) alkyl -; wherein at least one of R2 and R8 is alkyl- (C1-C10), alkynyl- (C2-C12), alkoxy- (C1-C10), - (OCH2CH2) s- Oalkyl (C1-C6), - ( CH2CH2O) s-(C1-C6) alkyl, NH2, -NH (C1-C6) alkyl, -CONR5R6, alkyl- (C1-C6) -CO-NR5R6, alkyl- (C1-C6) -C (> = O) -NR5R6, -COOR7, alkyl- (C1-C6) -C (> = O) -OR7, cycloalkyl- (C3-C12), aryl- (5 to 12 members), (aril (5 to 12 members) ) -C1-C6 alkyl, heteroaryl- (5 to 12 members), bicycloheterocycle- (7 to 12 members), phenyl, benzyl or naphthyl; each of which is optionally substituted with one or two substituents that are independently selected from the group consisting of OH, halo, -C (halo) 3, -CH (halo) 2, -CH2 (halo), alkyl- (C1 -C6), alkenyl- (C2-C6), alkynyl- (C2-C6), hydroxyalkyl- (C1-C6), dihydroxyalkyl- (C1-C6), alkoxy- (C1-C6), (alkoxy (C1-C6) )) CO-C1-C6 alkoxy, phenyl, benzyl, -NH2, CN, OR4, -CONR5R6, -COOR7, alkyl- (C1-C6) -C (> = O) -OR7, alkoxy- (C1- C6) -COOR7, - (OCH2CH2) s-Oalkyl (C1-C6), -NH-SO2alkyl (C1-C6), -N (SO2alkyl (C1-C6)) 2, -C (> = NH) NH2, - NH-C (> = O) - (C1-C6) alkyl, -NH-C (> = O) -NH2, -NH-C (> = O) -NH-(C1-C6) alkyl, -NH- C (> = O) aryl- (5 to 12 members), -NH-alkyl (C1-C6) -C (> = O) -OR7, -NHC (> = O) -alkyl (C1-C6) - CO-OR7, aryl- (5 to 12 members), -NH-(C1-C6) alkyl-C (O) -NR5R6, -C (O) NH-C1-C6 alkyl -COOR7, heteroaryl- ( 5 to 12 members), and (heteroaryl (5 to 12 members)) - (C1-C6) alkyl; R3a and R3b are each independently selected from hydrogen, alkyl- (C1-C10), alkenyl- (C2-C10), alkynyl- (C2-C10), alkoxy- (C1-C10), hydroxyalkyl- (C1-C6) , -alkyl (C1-C6) -C (> = O) alkoxy- (C1-C6), alkyl- (C1-C6) - 45 CN, alkyl- (C1-C6) -COOR7, or (aryl (of 5 to 12 members)) - (C1-C6) alkoxy- (C1-C6) alkyl; R4 is alkyl- (C1-C6); R4 is alkyl- (C1-C6); R5 and R6 are each independently hydrogen, alkyl- (C1-C6), alkyl- (C1-C6) CO-OR7, or (C1-C6) alkyl-CONH-; R7 is selected from hydrogen or (C1-C6) alkyl; R9 and R10 are each independently selected from hydrogen or (C1-C6) alkyl; R12 and R13 are each independently selected from hydrogen or alkyl- (C1-C10); each of which is substituted with one or two substituents independently selected from the group consisting of -CONR5R6, -COOR7 and heteroaryl - (5 to 12 members); G is selected from O, -OCO-, -C (> = O), NH, NR ', S, SO or SO2; |
| priorityDate | 2010-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 860.