abstract |
A compound of formula (I), ** Formula **, a N-oxide form, an addition salt, or a stereochemically isomeric form thereof, wherein n is 0 or 1; s is 0 or 1; X is -N> = or -CR4> =, where R4 is hydrogen or taken together with R1 can form a bivalent radical of formula -CH> = CH-CH> = CH-; Y is -N <or -CH <; Q is -NH-, -O-, -C (O) -, -CH2-CH2- or -CHR5-, where R5 is hydrogen, hydroxy, C1-6 alkyl, aryl-C1-6 alkyl, C1-6alkyl-oxycarbonyl, C1-6alkyl-oxy-C1-6alkyl-amino or haloindazolyl; R1 is C1-6alkyl or thienyl; R2 is hydrogen; R3 is hydrogen, C1-6 alkyl, or a radical selected from -NR6R7 (a-1), -OH (a-2), -O-R8 (a-3), -S-R9 (a-4), or -C≡N (a-5), where R6 is -CHO, C1-6alkyl, hydroxy-C1-6alkyl, C1-6alkylcarbonyl, di (C1-6alkyl) amino-alkyl C1-6, C1-6-alkyl-carbonylamino-C1-6-alkyl, piperidinyl-C1-6-alkyl, piperidinyl-C1-6-alkyl-aminocarbonyl, C1-6-alkyl-oxy, C1-6-alkyl-oxy-alkyl C1-6, thienylC1-6alkyl, pyrrolylalkyl- C1-6, aryl-C1-6alkyl-piperidinyl, arylcarbonylalkyl- C1-6alkyl, arylcarbonylpiperidinylC1-6alkyl, or haloindazolylpiperidinylC1-6alkyl, or arylalkylC1-6 (C1-6alkyl) amino-C1-6alkyl; and R7 is hydrogen or C1-6 alkyl; R8 is C1-6alkyl, C1-6alkylcarbonyl or di (C1-6alkyl) amino-C1-6alkyl; and R9 is di (C1-6alkyl) amino-C1-6alkyl; or R3 is a group of formula - (CH2) t-Z- (b-1), where t is 0, 1 or 2; Z is a heterocyclic ring system selected from ** Formula ** in which each R10 is independently hydrogen, C1-6 alkyl, aminocarbonyl, hydroxy, ** Formula ** C1-6alkyl-C1-6alkyl-alkyl, C1-alkyl -6-oxy-C1-6-alkyl-amino, di (C2-6-phenyl-alkenyl), piperidinyl-C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkyl-C1-6-alkyl, aryloxy ( hydroxy) C1-6alkyl, haloindazolyl, aryl-C1-6alkyl, aryl-C2-6alkenyl, morpholino, C1-6alkyl-imidazolyl, or pyridinyl-C1-6alkyl-amino; each R11 is independently hydrogen, hydroxy, piperidinyl, or aryl; Aryl is phenyl or phenyl substituted with halo, C1-6 alkyl or C1-6 alkyl-oxy. |