http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2564418-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f7b665fb8f15d0e2b0911539d39f8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 |
| filingDate | 2007-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6211ba8e9713716c2af242952f68a472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84ec5a25b3c0539e4566876dc709b310 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ae3f13b37cd00828c1fc420796b12eb |
| publicationDate | 2016-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2564418-T3 |
| titleOfInvention | Sigma receptor compounds |
| abstract | Compounds of general formula (I), ** Formula ** in which A represents an NR3 group; m is selected from 0, 1, 2; n is selected from 0, 1, 2, 3, 4; the dashed line ----- represents a single or double bond; R1 and R2, identical or different, represent a hydrogen atom; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted cycloalkyl group that is optionally fused to other at least monosubstituted monocyclic or polycyclic ring systems; an optionally at least monosubstituted aryl group that is optionally fused to other at least monosubstituted monocyclic or polycyclic ring systems; an optionally at least monosubstituted heterocyclyl group that is optionally fused to other at least monosubstituted polycyclic or monocyclic ring systems; an optionally at least monosubstituted, branched or unbranched, saturated or unsaturated alkyl-cycloalkyl group in which the cycloalkyl group is optionally at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; an optionally at least branched or unbranched, saturated alkyl monosubstituted aryl group in which the aryl group may optionally be at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; an optionally at least monosubstituted, branched or unbranched, saturated alkyl heterocyclyl group in which the heterocyclic group optionally can be at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; a group (C> = O) -R7; a group (C> = O) -O-R7; a (SOt) -R7 group; an NR7R7a group; a group (C> = O) -NR7R7a; an O-R7 group; or together with the bridging nitrogen atom form a heterocyclyl group containing at least one monocyclic, optionally at least monosubstituted heteroatom that is optionally fused with a monocyclic or polycyclic ring system at least optionally monosubstituted and / or linked via groups linear alkylene and / or is optionally linked via a spirocyclic linkage to an optionally at least monosubstituted monocyclic or polycyclic ring system; t is selected from 0, 1, 2 or 3; R3 represents a hydrogen atom; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted cycloalkyl group that is optionally fused to other at least monosubstituted polycyclic or monocyclic ring systems; an optionally at least monosubstituted aryl group that is optionally fused to other at least monosubstituted monocyclic or polycyclic ring systems; and optionally an at least monosubstituted heterocyclyl group that is optionally fused to other monocyclic or polycyclic ring systems, at least monosubstituted; an optionally at least monosubstituted, branched or unbranched, saturated or unsaturated alkyl-cycloalkyl group, wherein the cycloalkyl group can optionally be at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; an optionally at least monosubstituted, branched or unbranched, saturated alkyl aryl group in which the aryl group can optionally be at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; an optionally at least monosubstituted, branched or unbranched, saturated alkyl heterocyclyl group, wherein the heterocyclyl group can optionally be at least monosubstituted and / or fused with a monocyclic or polycyclic ring system; R4 and R5, identical or different, represent a hydrogen atom; F, Cl; Br; I; CF3; OH; CN; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted C1-6 alkoxy group; an optionally at least monosubstituted cycloalkyl group; an aryl group optionally at least monosubstituted; an optionally at least monosubstituted heterocyclyl group; an optionally at least monosubstituted, branched or unbranched, saturated alkyl-cycloalkyl group; an optionally at least saturated branched or unbranched monosubstituted alkyl aryl group; an optionally at least monosubstituted, branched or unbranched, saturated alkyl heterocyclyl group; or together form an optionally at least monosubstituted 3-6 membered ring system; R6 represents a hydrogen atom; F, Cl; Br; I; CF3; OH; CN; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted C1-6 alkoxy group; an optionally at least monosubstituted cycloalkyl group; an aryl group optionally at least monosubstituted; an optionally at least monosubstituted heterocyclyl group; an optionally at least monosubstituted, branched or unbranched, saturated alkyl-cycloalkyl group; an optionally at least saturated branched or unbranched monosubstituted alkyl aryl group; an optionally at least saturated branched or unbranched monosubstituted alkyl heterocyclyl group; R7 and R7a, identical or different represent a hydrogen atom; F, Cl; Br; I; CF3; OH; CN; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted C1-6 alkoxy group; an optionally at least monosubstituted cycloalkyl group; an aryl group optionally at least monosubstituted; an optionally at least monosubstituted heterocyclyl group; an optionally at least monosubstituted, branched or unbranched, saturated or unsaturated alkyl-cycloalkyl group; an optionally at least monosubstituted, branched or unbranched, saturated alkyl aryl group; an optionally at least saturated branched or unbranched monosubstituted alkylheterocyclyl group; R8 represents a hydrogen atom; F, Cl; Br; I; CF3; OH; CN; an optionally at least monosubstituted, linear or branched, saturated or unsaturated aliphatic radical; an optionally at least monosubstituted C1-6 alkoxy group; an optionally at least monosubstituted cycloalkyl group; an aryl group optionally at least monosubstituted; an optionally at least monosubstituted heterocyclyl group; an optionally at least monosubstituted, branched or unbranched, saturated or unsaturated alkyl-cycloalkyl group; an optionally at least saturated branched or unbranched monosubstituted alkyl aryl group; an optionally at least monosubstituted, branched or unbranched, saturated alkyl heterocyclyl group; with the provisos that if R3 is H, m and n are each 1, the dashed line ---- represents a single bond, R4, R5 and R6 are hydrogen and R8 is CH2OH, R1 and R2 cannot form together with the atom of bridging nitrogen, an unsubstituted pyrrolidine; if R3 is H, m and n are each 1, the dashed line ---- represents a single bond and R4, R5, R6 and R8 are hydrogen, R1 and R2 cannot form together with the bridging nitrogen atom, an unsubstituted pyrrolidine; if R3 is H, m and n are each 1, R4, R5 and R6 are hydrogen, the dashed line ---- represents a single bond, and R1 and R2 together with the nitrogen atom forming an unsubstituted pyrrolidine , R8 cannot be CH> = Het, Het being a phenyl-substituted 1,3-dihydroindole-2-one; if R3 is H, m is 1, n is 0, R4, R5, R6 and R8 are hydrogen, and the dashed line ---- \ - represents a double bond, one of R1 or R2 cannot be hydrogen, when the other is C (O) -cyclohexyl; optionally in the form of one of the stereoisomers, preferably enantiomers or diastereoisomers, a racemate or in the form of a mixture of at least two of the stereoisomers, preferably enantiomers and / or diastereoisomers, in any mixing ratio, or a corresponding salt thereof , or a corresponding solvate thereof, in which the cycloalkyl radical or group is understood to mean saturated and unsaturated, but non-aromatic, cyclic hydrocarbons (without any ring heteroatoms), which may be unsubstituted or mono or polysubstituted, in those in which an alkyl radical or group are saturated and unsaturated, linear or branched hydrocarbons, which may be unsubstituted or mono or polysubstituted, and in which, in relation to the alkyl or aliphatic group, unless otherwise defined, the "substituted term" means the replacement of at least one hydrogen radical, by F, Cl, Br, I, NH2, SH or OH, in which in relation to ar yl or alkyl-aryl, cycloalkyl or alkyl-cycloalkyl, heterocyclyl or alkyl-heterocyclyl, substituted is understood to mean, unless otherwise defined, the substitution of the aryl or alkyl-aryl, cycloalkyl or alkyl-cycloalkyl ring system. ; heterocyclyl or alkyl heterocyclyl by OH, SH,> = O, halogen (F, Cl, Br, I), CN, NO2, COOH; NRxRy, Rx and Ry independently being H or saturated or unsaturated, linear or branched, substituted or unsubstituted C 1-6 alkyl; a substituted or unsubstituted, linear or branched, saturated or unsaturated -O-C 1-6 alkyl (alkoxy); a substituted or unsubstituted, linear or branched, saturated or unsaturated, -S-C1-alkyl; a substituted or unsubstituted, linear or branched, saturated or unsaturated, substituted or unsubstituted -C (O) -C1-6 alkyl group; a substituted or unsubstituted, linear or branched, saturated or unsaturated, substituted or unsubstituted -C (O) -O-C1-6 alkyl group; a substituted or unsubstituted aryl or alkyl-aryl; a substituted or unsubstituted cycloalkyl or alkyl-cycloalkyl; a substituted or unsubstituted heterocyclyl or alkyl heterocyclyl. |
| priorityDate | 2006-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 149.