http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2564147-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0bf0928b608797b70bbc2b91c7e52e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-62 |
| filingDate | 2006-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3262710f2b97da4a04c587b836f811e7 |
| publicationDate | 2016-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2564147-T3 |
| titleOfInvention | Procedure for the preparation of optically active aminoalkylphenols |
| abstract | Process for the preparation of optically active compounds of formulas IS and/or IR**Formula** in which n represents 0, 1 or 2 and m represents 0, 1 or 2, comprising the following steps: (i) reacting a mixture of enantiomers of formula II**Formula** in which P represents a protecting group, which is selected from tert-butyl and an optionally substituted benzyl group on the phenyl ring, with an acylating agent in the presence of a hydrolase , obtaining a mixture in which one enantiomer of compound (II) is essentially in the acylated form and the other enantiomer of compound (II) is essentially in the unacylated form; (ii) separating the unacylated enantiomer of compound (II) from the mixture obtained in step (i); (iii) deprotecting the unacylated enantiomer of compound (II) obtained in step (ii) to give amine (I-S) or (IR); and (iv) if desired, hydrolyzing the essentially acylated enantiomer of compound (II) obtained in step (i) to give the corresponding non-acylated enantiomer of amine (II) and further deprotecting to give amine (IR) or ( SI); obtaining the compound of formula (II) (a) by protecting a compound of formula (III)**Formula** in the OH group with obtaining compound (IV)**Formula** and (b) by subjecting the compound (IV) to a reductive amination, obtaining the compound of formula (II). |
| priorityDate | 2005-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.