http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2563902-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68cdc4b020ae1cec80f5bc89c4d22793 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 |
| filingDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03aaa29ca7bfa206a1bb86fd63762585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1792d8b2b25ffec5e1de74272759e3e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4d11d51e5590f47536cfe765b947375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd2efa913fb98edf18eab76784b0e06d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04e453f2a355937133886541d05787c |
| publicationDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2563902-T3 |
| titleOfInvention | N- (heteroaryl) -sulfonamide derivatives useful as S100 inhibitors |
| abstract | A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof; where W is N or CH; X is N or CR1; Y is N or CR2; Z is N or CR3; at least one and at most two of W, X, Y and Z are N; R1 is H, halogen, S (O) 2 C1-C3 alkyl, cyano, or C1-C3 alkyl optionally substituted with one or more halogen (s); R2 is H, halogen, cyano, C (O) OH, C (O) C1-C3 alkyl, C1-C3 alkyl optionally substituted with one or more F; hydroxy-C1-C3 alkyl, S (O) 2 C1-C3 alkyl, S (O) 2 C3-C6 cycloalkyl or S (O) 2 hydroxy C1-C3 alkyl; 3 is H, halogen or cyano; V is (CHR4) m; m is 0 or 1; R4 is H or C1-C3 alkyl optionally substituted with one or more halogen (s); Ar is ** Formula ** R5 is H, halogen or cyano; R6 is H or halogen; R7 is H, halogen, C1-C3 alkyl, cyano, S (O) 2 C1-C3 alkyl, or phenyl; R8 is H, halogen, C1-C3 alkyl optionally substituted with one or more F; C1-C3 alkoxy optionally substituted with one or more F; phenoxy, NHR11, or NR11R12; R9 is H, halogen, cyano, C1-C3 alkyl optionally substituted with one or more F; C1-C3 alkylthio optionally substituted with one or more F; C1-C3 alkoxy optionally substituted with one or more F; or C (O) NR13R14; R10 is H, halogen, cyano, C1-C3 alkyl optionally substituted with one or more F; C1-C3 alkylthio optionally substituted with one or more F; C1-C3 alkoxy optionally substituted with one or more F; or C (O) NR13R14; R11 is C1-C3 alkyl; R12 is C1-C3 alkyl; or R11 and R12, together with the nitrogen atom to which they are both attached, form a ring of formula ** Formula ** R13 is H or C1-C3 alkyl; and R14 is H or C1-C3 alkyl; provided that the compound is not selected from 3,4-difluoro-N- (2-hydroxypyridin-3-yl) benzene-1-sulfonamide, N- [5-bromo-3-hydroxypyridin-2-yl] -4 -methylbenzenesulfonamide, N- (1,2-dihydro-2-oxo-3-pyridinyl) -2- (trifluoromethyl) -benzenesulfonamide, 4-chloro-N- (1,2-dihydro-2-oxo-3-pyridinyl) -3- (trifluoromethyl) -benzenesulfonamide, 4-chloro-N- (3-hydroxy-2-pyridinyl) -benzenesulfonamide, 3-trifluoromethyl-N- (3-hydroxy-2-pyridinyl) -benzenesulfonamide, 4-methyl-N - (3-hydroxy-2-pyridinyl) -benzenesulfonamide, 4-methyl-N- (2-hydroxy-3-pyridinyl) -benzenesulfonamide, and 4-methyl-N- (2,3-dihydro-3-oxo-4 -pyridazinyl) -benzenesulfonamide or its 4-methyl-N- (3-hydroxy-4-pyridazinyl) -benzenesulfonamide tautomer. |
| priorityDate | 2013-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 868.