http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2563816-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-58 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-228 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C15-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-58 |
| filingDate | 2012-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55ceb44dbafd3cb4cd71a2faf22821d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_473d53307949e338a07ea61b17817b7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95d34b75a0fb3a0bd83a28d1350937fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93524ce33f89a7859f07ca354f433389 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a7435fce459fac10585fc1cd7c342f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_550f4dc60023c41acdb58f6d50801176 |
| publicationDate | 2016-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2563816-T3 |
| titleOfInvention | Medetomidine preparation method |
| abstract | A method of preparing medetomidine, the method comprises a stage (N) and a stage (M1); step (M1) comprises a reaction (M1-reac); the reaction (M1-reac) is a reaction between a compound selected from the group consisting of a compound of formula (XXI), the hydrate of the compound of formula (XXI) and a hemiacetal of the compound of formula (XXI), said being hemiacetal of the compound of formula (XXI) the product of an addition reaction between aldehyde as represented in formula (XXI) and an alcohol selected from the group consisting of tert-butanol and isopropanol, a reagent (M-reac) and a reagent (MA) in a solvent (M-dissolv); the reagent (M-reac) is selected from the group consisting of p-toluenesulfonylmethyl isocyanide, trifluoromethanesulfonylmethyl isocyanide, methanesulfonylmethyl isocyanide, benzenesulfonylmethyl isocyanide, 4-acetamidobenzenesulfonyl isocyanide mixtures; Reagent (M-A) is selected from the group consisting of ammonia, sulfamic acid, p-toluenesulfonamide, benzenesulfonamide, 4-acetamidobenzenesulfonamide, tritylamine, formamide, urea, urotropin, ethyl carbamate, acetamide and mixtures thereof; The solvent (M-dissolv) is selected from the group consisting of N, N-dimethylformamide, C1-6 alkanol, formamide, 1,2-dimethoxyethane, NMP, toluene, acetonitrile, propionitrile, ethyl carbamate, N, N- dimethylacetamide, water, acetamide and mixtures thereof; and wherein the compound of formula (XXI) is prepared in step (N); step (N) comprises a reaction (N-reac); the reaction (N-reac) is a reaction of the compound of formula (XXII) with a catalyst (N-cat); The catalyst (N-cat) is selected from the group consisting of acetic acid, formic acid, trifluoroacetic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, camphorsulfonic acid, HCl, HBr, H2SO4, HNO3, H3PO4, HClO4, BCl3, BBr3, BF3OEt2, BF3SMe2, BF3THF, MgCl2, MgBr2, MgI2, AlCl3, Al (C1-4 alkyl) 3, SnCl4, TiCl4, Ti (C1-4 alkyl) 4, ZrCl4, Bi2O3, BiCl3, ZnCl2, PbCI2, FeCl3, ScCI3, NiCl2, Yb (OTf) 3, Yb (Cl) 3, GaCl3, AIBr3, Ce (OTf) 3, LiCl, Cu (BF4) 2, Cu (OTf) 2, NiBr2 (PPh3) 2, NiBr2, NiCl2, Pd (OAc) 2, PdCl2, PtCl2, InCl3, an acidic inorganic solid substance, an acidic ion exchange resin, carbon treated with inorganic acid and mixtures thereof. |
| priorityDate | 2012-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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