| abstract |
A compound of formula (II) ** Formula ** or a pharmaceutically acceptable salt thereof, wherein, X1, X2, X3 and X4 are each independently selected from CH and N; each occurrence of L is independently selected from -CH2NHC (O) -and -CH2NHS (O) 2-; each occurrence of P is independently selected from -CH2NHC (O) -and -CH2NHS (O) 2-; Each occurrence of Q is independently selected from C1-8alkyl, haloC1-8alkyl, C1-8alkoxyC1-8alkyl, hydroxyC1-8alkyl, carboxyC1-8alkyl, C3-12cycloalkyl, C6-14aryl, 3-15 membered heterocyclyl, and 5-heteroaryl -14 members; each occurrence of W is independently selected from isopropyl, tert-butyl, trifluoromethyl, 1-fluoro-2- methylpropan-2-yl, 1-Hydroxy-2-methylpropan-2-yl and cyclopropyl; Each occurrence of R1 is independently selected from cyano halo, C1-8alkyl, C1-8alkoxy, haloC1-8alkoxyC1-8alkyl, haloC1-8alkyl, C3-6cycloalkyl, heterocyclylC1-8alkyl 5-membered, 5-membered heteroaryl, C1-8 heteroaryl members, and -C≡CR; Each occurrence of R2 is independently selected from cyano, C1-8alkyl, C1-8alkoxy, haloC1-8alkyl, C3-6cycloalkyl, 5-membered heteroaryl, -C (O) NHR, -NHC (O) R, -S (O ) 2NHR and -C≡CR; each occurrence of R is independently selected from C1-8alkyl, C3-12cycloalkyl, and C6-14aryl; "m" is an integer that varies from 0 to 3, both inclusive; "n" is an integer that varies from 0 to 3, both inclusive; "s" is an integer that varies from 0 to 1, both inclusive; and "t" is an integer that varies from 0 to 1, both inclusive; with the proviso that (i) "s" and "t" are not "0" simultaneously, and (ii) "m" and "n" are not "0" simultaneously. |