http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2563152-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b755982699e3ea5199d569ee5f5344c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 |
| filingDate | 2012-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d61d87f05f53a0956d9b28b5b68a3cce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3737459b1f45a55a2ecc798eb662c989 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed6248ecdd4242024b6c84d882668833 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c27ccb3099c35a1fec3388ded90e5a68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8416da4d04b1aadfeba1fb622f3e0d54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f8548a7919d73c6289d74ee243ac141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125c76105ada417dd162bb8e8581b32c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5219309dd30d351e87d3f6f26ccefa78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1340f128bc8694647bfea4da730df13b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc96ee354c06e15a86ba0ad61faa9c33 |
| publicationDate | 2016-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2563152-T3 |
| titleOfInvention | Triazolopyridine compounds as PIM kinase inhibitors |
| abstract | A compound of general formula I ** Formula ** and its pharmaceutically acceptable stereoisomers, salts and solvates, wherein: R1 is H, halogen, CN, OH, (C1-6) alkyl, fluoroalkyl (C1-6), difluoroalkyl ( C1-6), trifluoroalkyl (C1-6), hydroxyalkyl (C1-6), cyanoalkyl (C1-6), (C1-3 alkoxy) alkyl (C1-6) (optionally substituted with hydroxy), di (C1- alkoxy 3) C1-6 alkyl, C1-6 alkoxy, C1-6 fluoroalkoxy, C1-6 difluoroalkoxy, trifluoroalkoxy (C1-6), hydroxyalkoxy (C2-6), cyanoalkoxy (C1-6) , (C1-3 alkoxy) (C2-6) alkoxy, di (C1-3 alkoxy) (C2-6) alkoxy, (C3-6 cycloalkyl) methoxy, oxetanylmethoxy (optionally substituted with methyl), (C1-6 alkyl) sulfanyl, -C (> = O) NRaRb, -CH2C (> = O) NRcRd, or (C3-6) cycloalkyl optionally substituted with -CH2OH or -CH2O (C1-4 alkyl); Ra, Rb, Rc and Rd are independently selected from H and (C1-4) alkyl; R2 is H, halogen, CN, OH, (C1-6) alkyl, fluoroalkyl (C1-6), difluoroalkyl (C1-6), trifluoroalkyl (C1-6), hydroxyalkyl (C1-6), (C1-3 alkoxy ) (C1-6) alkyl, (C1-6) alkoxy (optionally substituted with (C1-6 alkyl) C (> = O) O-, amino (C1-6 alkyl) C (> = O) O-, or phenyl (C> = O) O-), fluoroalkoxy (C1-6), difluoroalkoxy (C1-6), trifluoroalkoxy (C1-6), hydroxyalkoxy (C2-6), (C1-3 alkoxy) alkoxy (C2-6 ), (C3-6 cycloalkyl) methoxy, C3-6 cycloalkoxy (optionally substituted with OH), oxetanylmethoxy (optionally substituted with methyl), tetrahydropyranyloxy, (C1-6 alkyl) sulfanyl, hydroxy (C2-6 alkyl) sulfanyl, (C1-3 alkylsulfanyl) (C2-6) alkoxy, -COOH, hetAr1, -C (> = O) NReRf, -NReC (> = O) Rf, oxetanyl or cyclopropyl optionally substituted with - CH2OH or -CH2O (C1 alkyl -6); or R1 and R2 together with the atoms to which they are attached, form a 5-6 membered heterocyclic ring having 1-2 ring heteroatoms, independently selected from O and N, wherein said ring is optionally substituted with alkyl ( C1-4); hetAr1 is a 5-6 membered heteroaryl ring having 1 or 2 ring nitrogen atoms and is optionally substituted with one or more groups selected from (C1-6) alkyl; Re and Rf are independently H, (C1-6) alkyl or cyclopropyl optionally substituted with (C1-4) alkyl; R3 is H, halogen or (C1-6) alkyl; R4 is ** Formula ** R5 is CF3, CH2F, CHF2, methyl or ethyl; R5a is H or methyl; or R5 and R5a together with the atom to which they are attached form a cyclopropyl ring; R6 is H, NH2, OH, (C1-6 alkyl) NH-, fluoro (C1-6 alkyl) NH-, hydroxy (C1-6 alkyl) NH-, (C3-6 cycloalkyl) CH2NH-, (C1- alkyl 6) C (> = O) NH-, (C1-6 alkyl) OC (> = O) NH- (optionally substituted with 5-methyl-2-oxo-1,3-dioxol-4-yl), or aminoalkyl (C1-6) -; R7 is H, (C1-6) alkyl, fluoroalkyl (C1-6) or hydroxyalkyl (C1-6); or R6 and R7 together with the atom to which they are attached form a 5-6 membered spirocyclic heterocycle having a ring nitrogen atom; R8 is H, halogen, OH, or (C1-6) alkoxy, or R6 and R8 together with the carbon atoms to which they are attached form a cyclopropyl ring optionally substituted with NH2; R9 is H, or R6 and R9 together form a linker group having the formula -CH2NH- that connects the carbon atoms to which it is attached; and R10 is H or halogen. |
| priorityDate | 2011-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.