http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2562770-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-377 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 |
| filingDate | 2005-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcb86e7658d28d2bf16b68527a5d5868 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c05b6adb2eb4ab59ee995378a71c5acd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_839e7cd786d9c1b1e2f1b5f273b1aacf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6909efc0815728d88a037ea9c4be9401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3f0a646b2a5bbe6b521fb304f6b813f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fefaa6472d42d66702af592efa42586c |
| publicationDate | 2016-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2562770-T3 |
| titleOfInvention | Process for the production of [2- (4-fluoro-benzyl) -phenyl] -acetic acid |
| abstract | Process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, comprising the subsequent steps a) to e): a) reacting phthalic acid anhydride with fluorobenzene in a Friedel reaction Crafts using fluorobenzene itself as the solvent and aluminum chloride as the Lewis acid at reflux temperature, where aluminum chloride is used in a molar ratio to acid anhydride that is >2:1 ; b) by reducing the product obtained in step a) together with the ketone moiety using hydrogen gas, optionally in the presence of a Pd/C catalyst, and using isopropanol (iPrOH) as the solvent; c) reducing the product obtained in step b) with 2.3 equivalents of sodium dihydro-bis (2-methoxy-ethoxy) aluminate (Red-Al) to form the corresponding alcohol; d) chlorinating the alcohol obtained in step c) using an aqueous hydrochloric acid as the chlorinating agent, at 90 ºC in a closed container, and e) inserting CO into the product obtained in step d) by means of an appropriate catalytic system containing Pd, by reacting with CO in a mixture of THF and H2O in the presence of a) sodium acetate, K2C03 or Et3N and b) triphenylphosphine. |
| priorityDate | 2004-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.