http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2562183-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate | 2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_960b46371a8b88334e216a4a968eeedb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d630df8e0978f99858e02c7a12f6d25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83ace451ea596ccecb95152efc5ed9ae |
| publicationDate | 2016-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2562183-T3 |
| titleOfInvention | Benzonaphthyridineamines as autotaxin inhibitors |
| abstract | Compounds of formula (I) ** Formula ** in which: D represents Ar or Het, Ar represents phenyl, indanyl, naphthyl or biphenyl unsubstituted or substituted one or more times, Het represents a saturated one or two ring heterocycle, partially unsaturated or aromatic with 1, 2, 3 or 4 atoms of N, O and / or S that may be unsubstituted or substituted one or more times, X, Y are each absent independently of each other, represent -CH2-, - (CH2) 2-, -C (O) -, -CHOH- or - CH2OC (O) -, where only one of the residues X or Y may be absent, R each independently represent H, A, Cyc, (CH2) qAr or (CH2) qHet and can be substituted once or several times with R6, where in the case of A and Cyc the chain of C or the ring of C can also be interrupted with O, R1 each independently represent between yes R, F, Cl, Br, I, OH,> = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3 , SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and may be substituted or once or several times with R6, R2, R3 each independently represent R, where optionally R2 and R3 together can also form Cyc or Het, which in turn can be substituted once or several times with R6, R4 represent each one independently of each other R, F, Cl, Br, I, OH,> = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and can be substituted one or more times with R6, R5 each independently represent R, F, Cl, Br, I, OH,> = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A , phenyl and may be substituted once or several times with R6, R6 each independently represent R, F, Cl, Br, I, OH,> = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR, CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl and, as long as from a chemical point of view, a substitution is possible , they can be substituted once or several times with R, F, Cl, Br, I, OH,> = O, CN, NO2, NRR, NHC (O) R, NHSO2R, OR, C (O) R, C (O) NRR , CF3, OCF3, SCF3, SO2CH3, SO3R, SO2R, SO2NR, SR, OA, A, phenyl, A represents a linear or branched alkyl with 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, where 1, 2, 3, 4, 5, 6 or 7 H atoms can be replaced by OR, CN, NRR, F and / or Cl and / or where one or two non-adjacent CH2 groups can be replaced by O, NH, S , SO, SO2 and / or by CH> = CH groups, Cyc represents a cyclic alkyl with 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13 or 14 C atoms, m represents 0 , 1, 2, 3, 4 or 5, n represents 0, 1, 2 or 3, p represents 0, 1, 2, 3 or 4, q represents 0, 1 or 2, as well as its salts, solvates, and stereoisomers for pharmaceutical use, including mixtures in all proportions. |
| priorityDate | 2010-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1204.