| abstract |
An article, comprising: a device (1310) comprising a substance transfer component (1302) for receiving a substance from the skin and / or from under the skin of a patient, and / or for providing a substance to the skin and / or a position below the skin of a patient, in which the device comprises a vacuum chamber (1303) having an internal pressure less than atmospheric pressure; and an environment, contained within an outer envelope (1300), which has a pressure that is less than about 50 mmHg below atmospheric pressure, the device surrounding the environment. |