| abstract |
A compound of Formula I: ** Formula ** wherein: R1 is independently H, CF3 or Me; R2 is independently OH, C1-4alkyl, C1-4alkyl, CH2OH, F, CH2OC1-4alkyl, CF3 or CF2H; R3 is morpholinyl, piperidinyl, pyrrolidinyl, or hexahydroazepinyl; all of which may be unsubstituted or substituted with one or two R8s; or R3 is N (C1-6alkyl) 2, wherein C1-6alkyl may be unsubstituted or substituted with OH or -OCH3; R4 is CF3, halo, OMe, or alkyl; R5 is halo, cyano, CF3, C1-5 alkyl, C2-4 alkenyl, pyrrolidinyl, morpholinyl, piperidinyl, phenyl, pyridyl, pyrazolyl, pyrrolyl, piperazinyl, pyrimidinyl, OH, O-C1-4alkyl-OR6, OCF3, OCH2CF3 , OCH2CN, OR6 or CH2R9; wherein pyrrolidinyl, morpholinyl, piperidinyl, phenyl, pyridyl, pyrazolyl, pyrrolyl, piperazinyl, or pyrimidinyl may be unsubstituted or substituted with one or two halo, OH, OR6, or R6; R6 is independently C1-4alkyl, C3-6cycloalkyl; R7 is independently halo, methyl or OMe; R8 is independently OH, C1-4alkyl, C1-4alkyl, CH2OH, F, CH2OC1-4alkyl, CF3 or CF2H; R9 is independently pyrrolidinyl, morpholinyl, or piperidinyl; R10 is independently H, CF3 or Me; n is independently 0, 1 or 2; X is N or C; y is 1 or 2; or one of its pharmaceutically acceptable salts. |